Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 1/20 | 0.50 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.48 |
| ▸ | KDM5A | P29375 | 1/20 | 0.48 |
| ▸ | FAAH | O00519 | 4/20 | 0.45 |
| ▸ | HCRTR2 | O43614 | 3/20 | 0.45 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.45 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.43 |
| ▸ | RBP4 | P02753 | 2/20 | 0.40 |
| ▸ | FURIN | P09958 | 1/20 | 0.40 |
| ▸ | BTK | Q06187 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | HTR2B | P41595 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30729521 | 0.88 | KDM5A (0.58) | EPHX2RIPK1KDM5AHCRTR2HCRTR1 | |
| SCHEMBL9596851 | 0.86 | KDM5A (0.50) | EPHX2RIPK1KDM5AFAAHHCRTR2 | |
| SCHEMBL6123620 | 0.86 | KDM5A (0.50) | EPHX2RIPK1KDM5AFAAHHCRTR2 | |
| SCHEMBL5152829 | 0.85 | EPHX2 (0.63) | EPHX2RIPK1KDM5AHCRTR2HCRTR1 | |
| Hydrochloric Acid SCHEMBL23928369 | 0.84 | EPHX2 (0.62) | EPHX2RIPK1KDM5AHCRTR2HCRTR1 | |
| SCHEMBL2146339 | 0.82 | FURIN (0.43) | EPHX2RIPK1KDM5AHCRTR2HCRTR1 | |
| SCHEMBL9597082 | 0.82 | EPHX2 (0.49) | EPHX2RIPK1KDM5AFAAHHCRTR2 | |
| SCHEMBL22196870 | 0.82 | BTK (0.52) | EPHX2RIPK1KDM5AHCRTR2HCRTR1 | |
| SCHEMBL28668608 | 0.81 | FURIN (0.42) | EPHX2RIPK1KDM5AHCRTR2HCRTR1 | |
| SCHEMBL3001240 | 0.80 | GPR119 (0.52) | EPHX2RIPK1KDM5AHCRTR2HCRTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2389382-A1 | Amino-heterocyclic compounds used as pde9 inhibitors | Pfizer Inc. (US) | 2011-11-30 | — | — | EP | disclosed |
| US-8041687-B2 | Dynamic generation of XML Schema for backend driven data validation | INTERNATIONAL BUSINESS MACHINES CORPORATION (US) | 2011-10-18 | — | — | US | disclosed |
| WO-2010084438-A1 | AMINO-HETEROCYCLIC COMPOUNDS USED AS PDE9 INHIBITORS | PFIZER INC. (US) | 2010-07-29 | — | — | WO | disclosed |