Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 5/20 | 0.54 |
| ▸ | EGFR | P00533 | 3/20 | 0.54 |
| ▸ | ABL1 | P00519 | 2/20 | 0.50 |
| ▸ | ABL2 | P42684 | 2/20 | 0.50 |
| ▸ | PIK3CD | O00329 | 8/20 | 0.41 |
| ▸ | ADK | P55263 | 1/20 | 0.41 |
| ▸ | HCAR1 | Q9BXC0 | 1/20 | 0.40 |
| ▸ | HPGDS | O60760 | 1/20 | 0.39 |
| ▸ | BTK | Q06187 | 3/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19731353 | 0.94 | SRC (0.60) | SRCEGFRABL1ABL2PIK3CD | |
| SCHEMBL19731371 | 0.90 | SRC (0.49) | SRCEGFRABL1ABL2PIK3CD | |
| SCHEMBL15914127 | 0.89 | SRC (0.53) | SRCEGFRABL1ABL2PIK3CD | |
| SCHEMBL15516700 | 0.89 | SRC (0.53) | SRCEGFRABL1ABL2PIK3CD | |
| SCHEMBL13858155 | 0.89 | SRC (0.53) | SRCEGFRABL1ABL2PIK3CD | |
| SCHEMBL14635891 | 0.89 | SRC (0.53) | SRCEGFRABL1ABL2PIK3CD | |
| SCHEMBL19731370 | 0.88 | SRC (0.66) | SRCEGFRABL1ABL2BTK | |
| SCHEMBL19731361 | 0.88 | SRC (0.52) | SRCEGFRABL1ABL2PIK3CD | |
| SCHEMBL15345425 | 0.83 | SRC (0.59) | SRCEGFRABL1ABL2PIK3CD | |
| SCHEMBL1442313 | 0.83 | SRC (0.59) | SRCEGFRABL1ABL2PIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3486244-A1 | NEW COMPOUND HAVING FGFR INHIBITORY ACTIVITY AND PREPARATION AND APPLICATION THEREOF | Shanghai Institute of Materia Medica, Chinese Academy of Sciences (CN) | 2019-05-22 | — | — | EP | disclosed |
| WO-2017215485-A1 | NEW COMPOUND HAVING FGFR INHIBITORY ACTIVITY AND PREPARATION AND APPLICATION THEREOF | 中国科学院上海药物研究所 | 2017-12-21 | — | — | WO | disclosed |