Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
| ▸ | TP53 | P04637 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | FKBP1A | P62942 | 3/20 | 0.44 |
| ▸ | POLB | P06746 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18377855 | 0.82 | SMN1; SMN2 (0.51) | SMN1; SMN2ALDH1A1USP2NPC1RAB9A | |
| SCHEMBL18367617 | 0.78 | SMN1; SMN2 (0.48) | SMN1; SMN2ALDH1A1USP2NPC1RAB9A | |
| SCHEMBL4961669 | 0.77 | SMN1; SMN2 (0.49) | SMN1; SMN2ALDH1A1USP2NPC1RAB9A | |
| SCHEMBL10203210 | 0.77 | SMN1; SMN2 (0.52) | SMN1; SMN2ALDH1A1NPC1RAB9AHSD17B10 | |
| SCHEMBL13242529 | 0.76 | FLT3 (0.46) | SMN1; SMN2ALDH1A1KDM4EIRAK4 | |
| SCHEMBL20438069 | 0.74 | NTRK1 (0.36) | KMT2ATSHRMEN1 | |
| SCHEMBL16171674 | 0.73 | NTRK1 (0.38) | KMT2ATSHRMEN1 | |
| SCHEMBL13103451 | 0.70 | SMN1; SMN2 (0.51) | SMN1; SMN2ALDH1A1NPC1RAB9AHSD17B10 | |
| SCHEMBL12171704 | 0.69 | KMT2A (0.49) | SMN1; SMN2ALDH1A1RAB9APOLBKMT2A | |
| SCHEMBL4751928 | 0.69 | MAPK1 (0.45) | ALDH1A1HSD17B10KMT2AIRAK4TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10316017-B2 | COT modulators and methods of use thereof | GILEAD SCIENCES, INC. (US) | 2019-06-11 | — | — | US | disclosed |
| US-20170362201-A1 | COT MODULATORS AND METHODS OF USE THEREOF | GILEAD SCIENCES, INC. | 2017-12-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170362201-A1 | COT MODULATORS AND METHODS OF USE THEREOF | BRDT, THRB, HCCS | SMN1; SMN2 4716/4885ALDH1A1 2149/4885USP2 2038/4885 |
| US-10316017-B2 | COT modulators and methods of use thereof | BRDT, THRB, HCCS | SMN1; SMN2 4716/4885ALDH1A1 2149/4885USP2 2038/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.