Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.65 |
| ▸ | FLT3 | P36888 | 3/20 | 0.63 |
| ▸ | ABCB1 | P08183 | 3/20 | 0.58 |
| ▸ | MAPT | P10636 | 5/20 | 0.55 |
| ▸ | POLB | P06746 | 3/20 | 0.55 |
| ▸ | NPC1 | O15118 | 2/20 | 0.55 |
| ▸ | RAB9A | P51151 | 2/20 | 0.55 |
| ▸ | KIT | P10721 | 1/20 | 0.55 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.55 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.55 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.55 |
| ▸ | RELA | Q04206 | 1/20 | 0.55 |
| ▸ | MAOB | P27338 | 2/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | TP53 | P04637 | 2/20 | 0.55 |
| ▸ | USP2 | O75604 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1976108 | 1.00 | MEN1 (0.65) | MEN1KMT2AALDH1A1FLT3ABCB1 | |
| SCHEMBL1976117 | 0.90 | MEN1 (0.65) | MEN1KMT2AALDH1A1FLT3ABCB1 | |
| SCHEMBL1421434 | 0.90 | MEN1 (0.65) | MEN1KMT2AALDH1A1FLT3ABCB1 | |
| SCHEMBL1973514 | 0.88 | ABCB1 (0.64) | MEN1KMT2AALDH1A1FLT3ABCB1 | |
| SCHEMBL1975891 | 0.88 | ABCB1 (0.64) | MEN1KMT2AALDH1A1FLT3ABCB1 | |
| SCHEMBL1974922 | 0.88 | HSD17B2 (0.62) | MEN1KMT2AALDH1A1MAPTPOLB | |
| SCHEMBL1974728 | 0.88 | HSD17B2 (0.62) | MEN1KMT2AALDH1A1MAPTPOLB | |
| SCHEMBL1975034 | 0.83 | POLB (0.64) | MEN1KMT2AALDH1A1FLT3ABCB1 | |
| SCHEMBL1975441 | 0.83 | POLB (0.64) | MEN1KMT2AALDH1A1FLT3ABCB1 | |
| SCHEMBL1980105 | 0.83 | ABCB1 (0.44) | MEN1KMT2AALDH1A1ABCB1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110144194-A1 | CHROMENONE DERIVATIVES USEFUL FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | AXOGLIA THERAPEUTICS (LU) | 2011-06-16 | — | — | US | disclosed |
| EP-2112145-A1 | Chromenone derivatives useful for the treatment of neurodegenerative diseases | AxoGlia Therapeutics S.A. (LU) | 2009-10-28 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110144194-A1 | CHROMENONE DERIVATIVES USEFUL FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | PARK7, CDR2, SNCA | MEN1 1507/4885KMT2A 3801/4885ALDH1A1 2339/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.