Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 7/20 | 0.68 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL902411 | 0.88 | PDE10A (0.72) | PDE10ANR1I2CYP3A4CYP2C9KCNH2 | |
| SCHEMBL15021733 | 0.85 | PDE10A (0.68) | PDE10ANR1I2CYP3A4CYP2C9KCNH2 | |
| SCHEMBL900621 | 0.84 | PDE10A (0.67) | PDE10ANR1I2CYP3A4CYP2C9KCNH2 | |
| SCHEMBL898907 | 0.81 | PDE10A (1.00) | PDE10ANR1I2CYP3A4CYP2C9KCNH2 | |
| SCHEMBL1970666 | 0.68 | LMNA (0.61) | POLBLMNA | |
| SCHEMBL7427658 | 0.66 | POLB (0.79) | PDE10APOLB | |
| SCHEMBL31346128 | 0.66 | POLB (0.79) | PDE10APOLB | |
| SCHEMBL7854448 | 0.65 | POLB (0.92) | PDE10APOLB | |
| SCHEMBL7006523 | 0.65 | POLB (1.00) | PDE10APOLB | |
| SCHEMBL19025148 | 0.64 | POLB (0.83) | PDE10APOLBLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2621276-B1 | 2-ALKOXY PYRIMIDINE PDE10 INHIBITORS | MERCK SHARP & DOHME (US) | 2017-12-27 | — | — | EP | disclosed |