Sugi Predict

Sugi Predict / Compounds / SCHEMBL1973337

SCHEMBL1973337

SCHEMBL1973337

Cc1nc(C(=O)NCC(=O)O)c(O)c2sc(-c3ccc(F)cc3)cc12.O=C(O)CNC(=O)c1ncc2c(-c3ccc(F)cc3)c(-c3ccc(F)cc3)sc2c1O

nearest known ligand 0.46

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
▸ EGLN1 Q9GZT9 19/20 0.46
▸ EGLN2 Q96KS0 4/20 0.41
▸ BBOX1 O75936 1/20 0.40
▸ THRA P10827 1/20 0.40
▸ THRB P10828 1/20 0.40
▸ SLC6A2 P23975 1/20 0.40
▸ SLC6A3 Q01959 1/20 0.40
▸ ASPH Q12797 1/20 0.40
▸ KDM8 Q8N371 1/20 0.40
▸ FTO Q9C0B1 1/20 0.40
▸ VEGFA P15692 1/20 0.39
▸ FLT1 P17948 1/20 0.39
▸ EGLN3 Q9H6Z9 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL965320 0.89 EGLN1 (0.57) EGLN1BBOX1THRATHRBSLC6A2
SCHEMBL965197 0.88 EGLN1 (0.57) EGLN1EGLN2VEGFAFLT1EGLN3
SCHEMBL966297 0.81 EGLN1 (0.57) EGLN1BBOX1THRATHRBSLC6A2
SCHEMBL969590 0.79 EGLN1 (0.58) EGLN1EGLN2FTOVEGFAFLT1
SCHEMBL5287623 0.78 EGLN1 (0.43) EGLN1EGLN2THRATHRB
SCHEMBL969347 0.76 EGLN1 (0.67) EGLN1EGLN2BBOX1THRATHRB
SCHEMBL968819 0.76 EGLN1 (0.58) EGLN1EGLN2VEGFAFLT1EGLN3
SCHEMBL1971895 0.72 PTGS1 (0.39) THRBSLC6A3
SCHEMBL966070 0.72 EGLN1 (0.60) EGLN1BBOX1THRATHRBSLC6A2
SCHEMBL2882476 0.71 EGLN1 (0.58) EGLN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1866318-B1 THIENOPYRIDINE COMPOUNDS, AND METHODS OF USE THEREOF FIBROGEN INC (US) 2011-06-22 — — EP disclosed