Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.38 |
| ▸ | NAMPT | P43490 | 6/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22015497 | 0.85 | EPHX2 (0.38) | EPHX2USP2SMN1; SMN2EPHX1HPGD | |
| SCHEMBL31184369 | 0.84 | GPR119 (0.39) | EPHX2USP2SMN1; SMN2EPHX1HPGD | |
| SCHEMBL19641350 | 0.83 | GPR119 (0.37) | EPHX2USP2SMN1; SMN2EPHX1HPGD | |
| SCHEMBL16925393 | 0.83 | GPR119 (0.37) | EPHX2USP2SMN1; SMN2EPHX1HPGD | |
| SCHEMBL30929681 | 0.83 | GPR119 (0.37) | EPHX2USP2SMN1; SMN2EPHX1HPGD | |
| SCHEMBL20951857 | 0.76 | EPHX1 (0.46) | EPHX2USP2SMN1; SMN2EPHX1HPGD | |
| SCHEMBL21807018 | 0.75 | USP2 (0.49) | EPHX2USP2SMN1; SMN2EPHX1HPGD | |
| SCHEMBL28499349 | 0.75 | USP2 (0.49) | EPHX2USP2SMN1; SMN2EPHX1HPGD | |
| SCHEMBL6228410 | 0.74 | USP2 (0.55) | EPHX2USP2SMN1; SMN2EPHX1HPGD | |
| SCHEMBL13858387 | 0.74 | HPGD (0.48) | EPHX2USP2SMN1; SMN2EPHX1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017216706-A1 | COMPOUNDS AND COMPOSITIONS FOR INHIBITING THE ACTIVITY OF SHP2 | NOVARTIS AG (CH) | 2017-12-21 | — | — | WO | disclosed |