Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.61 |
| ▸ | POLB | P06746 | 3/20 | 0.61 |
| ▸ | HTT | P42858 | 1/20 | 0.61 |
| ▸ | NPC1 | O15118 | 5/20 | 0.57 |
| ▸ | RAB9A | P51151 | 5/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.57 |
| ▸ | MEN1 | O00255 | 3/20 | 0.57 |
| ▸ | MAPT | P10636 | 2/20 | 0.57 |
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | QPCT | Q16769 | 1/20 | 0.53 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.52 |
| ▸ | NAMPT | P43490 | 1/20 | 0.51 |
| ▸ | ESR1 | P03372 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | P2RY6 | Q15077 | 1/20 | 0.49 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8769868 | 0.89 | SMN1; SMN2 (0.64) | SMN1; SMN2POLBHTTNPC1RAB9A | |
| SCHEMBL4463141 | 0.86 | NPC1 (0.53) | SMN1; SMN2POLBHTTNPC1RAB9A | |
| SCHEMBL3147407 | 0.86 | POLB (0.60) | SMN1; SMN2POLBHTTNPC1RAB9A | |
| SCHEMBL21254596 | 0.83 | SMN1; SMN2 (0.57) | SMN1; SMN2POLBHTTNPC1RAB9A | |
| SCHEMBL7399035 | 0.82 | KDM4E (0.56) | SMN1; SMN2POLBHTTNPC1RAB9A | |
| SCHEMBL1666122 | 0.82 | RAB9A (0.80) | SMN1; SMN2POLBHTTNPC1RAB9A | |
| SCHEMBL1608962 | 0.81 | HDAC6 (0.77) | SMN1; SMN2POLBHTTNPC1RAB9A | |
| SCHEMBL12411719 | 0.80 | NPC1 (0.60) | SMN1; SMN2POLBHTTNPC1RAB9A | |
| SCHEMBL1666119 | 0.80 | RAB9A (0.77) | SMN1; SMN2POLBHTTNPC1RAB9A | |
| SCHEMBL1382753 | 0.79 | DEGS1 (0.54) | SMN1; SMN2POLBHTTNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2334652-A1 | 1H-BENZ IMIDAZOLE-5-CARBOXAMIDES AS ANTI-INFLAMMATORY AGENTS | Boehringer Ingelheim International GmbH (DE) | 2011-06-22 | — | — | EP | disclosed |