Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 2/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
| ▸ | SUV39H2 | Q9H5I1 | 1/20 | 0.30 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.30 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.30 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19736996 | 0.91 | PIK3CD (0.30) | PIK3CD | |
| SCHEMBL19736995 | 0.84 | SUV39H2 (0.32) | PIK3CDSUV39H2KDM4C | |
| SCHEMBL19736845 | 0.82 | PIK3CD (0.51) | PIK3CDPIK3C2BPIK3CG | |
| SCHEMBL19736987 | 0.64 | KDM4C (0.35) | L3MBTL1KDM4C | |
| SCHEMBL23662550 | 0.61 | KDM4C (0.37) | L3MBTL1KDM4C | |
| SCHEMBL14027736 | 0.60 | KDM4C (0.38) | L3MBTL1KDM4C | |
| SCHEMBL18355699 | 0.60 | TACR1 (0.46) | KDM4C | |
| SCHEMBL17658749 | 0.59 | KDM4C (0.35) | L3MBTL1KDM4C | |
| SCHEMBL17649571 | 0.59 | KDM4C (0.33) | L3MBTL1KDM4C | |
| SCHEMBL18355473 | 0.58 | L3MBTL1 (0.38) | L3MBTL1KDM4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3472160-B1 | BICYCLIC PYRIDINE, PYRAZINE, AND PYRIMIDINE DERIVATIVES AS PI3K BETA INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2021-02-24 | — | — | EP | disclosed |
| WO-2017216292-A1 | BICYCLIC PYRIDINE, PYRAZINE, AND PYRIMIDINE DERIVATIVES AS PI3K BETA INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2017-12-21 | — | — | WO | disclosed |