Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 2/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.41 |
| ▸ | MC4R | P32245 | 1/20 | 0.40 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.39 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17145089 | 1.00 | ACE (0.49) | ACECYP2D6ALDH1A1HPGDKMT2A | |
| SCHEMBL19741732 | 1.00 | ACE (0.49) | ACECYP2D6ALDH1A1HPGDKMT2A | |
| SCHEMBL19741718 | 1.00 | ACE (0.49) | ACECYP2D6ALDH1A1HPGDKMT2A | |
| SCHEMBL19741674 | 0.92 | CYP2D6 (0.46) | ACECYP2D6ALDH1A1HPGDKMT2A | |
| SCHEMBL17144598 | 0.92 | CYP2D6 (0.46) | ACECYP2D6ALDH1A1HPGDKMT2A | |
| SCHEMBL17144597 | 0.92 | CYP2D6 (0.46) | ACECYP2D6ALDH1A1HPGDKMT2A | |
| SCHEMBL19741675 | 0.92 | CYP2D6 (0.46) | ACECYP2D6ALDH1A1HPGDKMT2A | |
| SCHEMBL19741744 | 0.84 | HSD11B1 (0.45) | ALDH1A1KMT2AHSD11B1OPRM1 | |
| SCHEMBL17145035 | 0.84 | HSD11B1 (0.45) | ALDH1A1KMT2AHSD11B1OPRM1 | |
| SCHEMBL19741734 | 0.84 | HSD11B1 (0.45) | ALDH1A1KMT2AHSD11B1OPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170369444-A1 | INHIBITORS OF HISTONE DEMETHYLASES | EPITHERAPEUTICS APS (DK) | 2017-12-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170369444-A1 | INHIBITORS OF HISTONE DEMETHYLASES | KDM1B, KDM3A, KDM1A | ACE 3020/4885CYP2D6 1476/4885ALDH1A1 1473/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.