Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.64 |
| ▸ | RAB9A | P51151 | 1/20 | 0.64 |
| ▸ | SMYD3 | Q9H7B4 | 19/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19079594 | 0.83 | SMYD3 (0.50) | NPC1RAB9ASMYD3 | |
| SCHEMBL17593134 | 0.83 | SMYD3 (0.77) | SMYD3 | |
| SCHEMBL19715058 | 0.83 | SMYD3 (0.77) | SMYD3 | |
| SCHEMBL17593014 | 0.83 | SMYD3 (0.77) | SMYD3 | |
| SCHEMBL17594846 | 0.82 | NPC1 (0.57) | NPC1RAB9ASMYD3 | |
| SCHEMBL19728178 | 0.82 | SMYD3 (0.62) | SMYD3 | |
| SCHEMBL19728180 | 0.82 | SMYD3 (0.62) | SMYD3 | |
| SCHEMBL19079589 | 0.81 | RAB9A (0.52) | NPC1RAB9ASMYD3 | |
| SCHEMBL17592584 | 0.80 | NPC1 (0.76) | NPC1RAB9ASMYD3 | |
| SCHEMBL19715241 | 0.80 | NPC1 (0.76) | NPC1RAB9ASMYD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3193606-B1 | ISOXAZOLE CARBOXAMIDES AS IRREVERSIBLE SMYD INHIBITORS | EPIZYME INC (US) | 2020-06-24 | — | — | EP | disclosed |
| US-10669243-B2 | Isoxazole carboxamides as irreversible SMYD inhibitors | Epizyme, Inc. (US) | 2020-06-02 | — | — | US | disclosed |
| US-20200123142-A1 | Substituted Cyclohexylamine Compounds | Epizyme, Inc. (US) | 2020-04-23 | — | — | US | disclosed |
| US-20190241529-A1 | Isoxazole Carboxamides as Irreversible SMYD Inhibitors | Epizyme, Inc. (US) | 2019-08-08 | — | — | US | disclosed |
| US-10179773-B2 | Isoxazole carboxamides as irreversible SMYD inhibitors | Epizyme, Inc. (US) | 2019-01-15 | — | — | US | disclosed |
| US-20170362191-A1 | Substituted Cyclohexylamine Compounds | Epizyme, Inc. (US) | 2017-12-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200123142-A1 | Substituted Cyclohexylamine Compounds | SMYD3, SMYD2, SNRPD3 | NPC1 2761/4885RAB9A 267/4885SMYD3 1/4885 |
| US-20190241529-A1 | Isoxazole Carboxamides as Irreversible SMYD Inhibitors | SMYD3, SMYD2, SNRPD3 | NPC1 3664/4885RAB9A 803/4885SMYD3 1/4885 |
| US-10179773-B2 | Isoxazole carboxamides as irreversible SMYD inhibitors | SMYD3, SMYD2, SNRPD3 | NPC1 3632/4885RAB9A 778/4885SMYD3 1/4885 |
| US-20170362191-A1 | Substituted Cyclohexylamine Compounds | SMYD3, SMYD2, SNRPD3 | NPC1 2761/4885RAB9A 267/4885SMYD3 1/4885 |
| US-10669243-B2 | Isoxazole carboxamides as irreversible SMYD inhibitors | SMYD3, SMYD2, SNRPD3 | NPC1 3664/4885RAB9A 803/4885SMYD3 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.