Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.53 |
| ▸ | ABL1 | P00519 | 1/20 | 0.31 |
| ▸ | RET | P07949 | 1/20 | 0.31 |
| ▸ | KDR | P35968 | 1/20 | 0.31 |
| ▸ | CDK7 | P50613 | 1/20 | 0.31 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.31 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.31 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.31 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.31 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30988525 | 0.78 | MAPK1 (0.46) | MAPK1ABL1RETKDRCDK7 | |
| SCHEMBL1585948 | 0.78 | MAPK1 (0.46) | MAPK1ABL1RETKDRCDK7 | |
| SCHEMBL3954043 | 0.77 | MAPK1 (0.44) | MAPK1ABL1RETKDRCDK7 | |
| SCHEMBL29488969 | 0.69 | MAPK1 (1.00) | MAPK1ABL1RETKDRCDK7 | |
| SCHEMBL649129 | 0.69 | MAPK1 (1.00) | MAPK1ABL1RETKDRCDK7 | |
| SCHEMBL30876173 | 0.69 | MAPK1 (0.35) | MAPK1CDK5 | |
| SCHEMBL1585882 | 0.65 | DYRK1B (0.44) | ABL1RETKDRCDK7CDK5 | |
| SCHEMBL24283772 | 0.65 | KDM4E (0.33) | CDK5 | |
| SCHEMBL29490926 | 0.65 | GRM4 (0.31) | — | |
| SCHEMBL19641301 | 0.65 | GRM4 (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017220431-A1 | FUSED PYRAZOLE DERIVATIVES AS JAK INHIBITORS | ALMIRALL, S.A. (ES) | 2017-12-28 | — | — | WO | disclosed |