Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 8/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.49 |
| ▸ | LMNA | P02545 | 10/20 | 0.49 |
| ▸ | HTT | P42858 | 6/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | SLC6A7 | Q99884 | 1/20 | 0.41 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19746916 | 0.83 | LMNA (0.61) | SMN1; SMN2KDM4ELMNAHTTL3MBTL1 | |
| SCHEMBL20964545 | 0.77 | LMNA (0.59) | SMN1; SMN2KDM4ELMNAHTTL3MBTL1 | |
| SCHEMBL20965398 | 0.75 | LMNA (0.57) | SMN1; SMN2KDM4ELMNAHTTL3MBTL1 | |
| SCHEMBL20964626 | 0.74 | LMNA (0.57) | SMN1; SMN2KDM4ELMNAHTTL3MBTL1 | |
| SCHEMBL20964633 | 0.74 | LMNA (0.57) | SMN1; SMN2KDM4ELMNAHTTL3MBTL1 | |
| SCHEMBL20965423 | 0.74 | LMNA (0.57) | SMN1; SMN2KDM4ELMNAHTTL3MBTL1 | |
| SCHEMBL20965401 | 0.74 | LMNA (0.68) | SMN1; SMN2KDM4ELMNAHTTL3MBTL1 | |
| SCHEMBL26298353 | 0.70 | KDM4E (0.56) | SMN1; SMN2KDM4ELMNAHTTL3MBTL1 | |
| Hydrochloric Acid SCHEMBL31410490 | 0.69 | KDM4E (0.55) | SMN1; SMN2KDM4ELMNAHTTL3MBTL1 | |
| SCHEMBL20964652 | 0.68 | LMNA (0.63) | SMN1; SMN2KDM4ELMNAHTTL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3471729-A1 | THERAPEUTIC COMPOUNDS | Rutgers, the State University of New Jersey (US) | 2019-04-24 | — | — | EP | disclosed |
| WO-2017222930-A1 | THERAPEUTIC COMPOUNDS | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) | 2017-12-28 | — | — | WO | disclosed |