Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 3/20 | 0.45 |
| ▸ | TOP1 | P11387 | 8/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.41 |
| ▸ | CLK2 | P49760 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2200702 | 0.92 | KCNH2 (0.46) | KCNH2TOP1KDM4EALDH1A1POLB | |
| SCHEMBL12427385 | 0.92 | KCNH2 (0.46) | KCNH2TOP1KDM4EALDH1A1POLB | |
| SCHEMBL12427322 | 0.88 | KCNH2 (0.43) | KCNH2TOP1KDM4EALDH1A1POLB | |
| SCHEMBL1974822 | 0.87 | TOP1 (0.48) | KCNH2TOP1KDM4EALDH1A1POLB | |
| SCHEMBL13744891 | 0.86 | KDM4E (0.46) | KCNH2TOP1KDM4EALDH1A1POLB | |
| SCHEMBL4257328 | 0.86 | KDM4E (0.46) | KCNH2TOP1KDM4EALDH1A1POLB | |
| SCHEMBL966711 | 0.86 | KDM4E (0.46) | KCNH2TOP1KDM4EALDH1A1POLB | |
| SCHEMBL12917302 | 0.86 | KDM4E (0.46) | KCNH2TOP1KDM4EALDH1A1POLB | |
| SCHEMBL12917329 | 0.86 | KDM4E (0.46) | KCNH2TOP1KDM4EALDH1A1POLB | |
| SCHEMBL968143 | 0.84 | EPHX2 (0.40) | KCNH2TOP1KDM4EALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1994020-B1 | Substituted quinolones III | AICURIS GMBH & CO KG (DE) | 2011-06-22 | — | — | EP | disclosed |