Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 3/20 | 0.46 |
| ▸ | TOP1 | P11387 | 8/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.42 |
| ▸ | CLK2 | P49760 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.42 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12427385 | 1.00 | KCNH2 (0.46) | KCNH2TOP1EPHX2KDM4EALDH1A1 | |
| SCHEMBL12427409 | 0.92 | KCNH2 (0.55) | KCNH2TOP1EPHX2KDM4EALDH1A1 | |
| SCHEMBL12427322 | 0.92 | KCNH2 (0.43) | KCNH2TOP1KDM4EALDH1A1POLB | |
| SCHEMBL1974487 | 0.92 | KCNH2 (0.45) | KCNH2TOP1KDM4EALDH1A1POLB | |
| SCHEMBL12917329 | 0.87 | KDM4E (0.46) | KCNH2TOP1KDM4EALDH1A1POLB | |
| SCHEMBL13744891 | 0.87 | KDM4E (0.46) | KCNH2TOP1KDM4EALDH1A1POLB | |
| SCHEMBL4257328 | 0.87 | KDM4E (0.46) | KCNH2TOP1KDM4EALDH1A1POLB | |
| SCHEMBL966711 | 0.87 | KDM4E (0.46) | KCNH2TOP1KDM4EALDH1A1POLB | |
| SCHEMBL12917302 | 0.87 | KDM4E (0.46) | KCNH2TOP1KDM4EALDH1A1POLB | |
| SCHEMBL2202775 | 0.86 | TOP1 (0.49) | KCNH2TOP1EPHX2PTGDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7977349-B2 | Substituted quinolones III | AICURIS GMBH & CO. KG (DE) | 2011-07-12 | — | — | US | disclosed |
| US-20090181996-A1 | SUBSTITUTED QUINOLONES III | BAYER HEALTHCARE AG (DE) | 2009-07-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090181996-A1 | SUBSTITUTED QUINOLONES III | IRF3, TPMT, TOP2A | KCNH2 3792/4885TOP1 4/4885EPHX2 3177/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.