2-Hydroxycinnamaldehyde

2-Hydroxycinnamaldehyde

SCHEMBL197452

O=C/C=C/c1ccccc1O

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CDK4 P11802 3/20 1.00
CCND1 P24385 3/20 1.00
TRIM24 O15164 1/20 0.60
TRIM33 Q9UPN9 1/20 0.60
NFKB1 P19838 2/20 0.57
JUN P05412 1/20 0.57
NFE2L2 Q16236 1/20 0.57
CA1 P00915 1/20 0.55
CA2 P00918 1/20 0.55
CA4 P22748 1/20 0.55
TRPA1 O75762 2/20 0.54
MAPT P10636 4/20 0.53
LMNA P02545 2/20 0.53
BCHE P06276 1/20 0.50
GUSB P08236 1/20 0.50
MAPK1 P28482 3/20 0.48
ALDH1A1 P00352 2/20 0.48
ALOX5 P09917 1/20 0.48
KDM4E B2RXH2 2/20 0.47
NPC1 O15118 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
2-Hydroxycinnamaldehyde SCHEMBL691039 1.00 CDK4 (1.00) CDK4CCND1TRIM24TRIM33NFKB1
2-Hydroxycinnamaldehyde SCHEMBL31388535 1.00 CDK4 (1.00) CDK4CCND1TRIM24TRIM33NFKB1
2-Hydroxycinnamaldehyde SCHEMBL29847322 1.00 CDK4 (1.00) CDK4CCND1TRIM24TRIM33NFKB1
2-Hydroxycinnamaldehyde SCHEMBL2192777 1.00 CDK4 (1.00) CDK4CCND1TRIM24TRIM33NFKB1
SCHEMBL15272147 0.91 CDK4 (0.84) CDK4CCND1TRIM24TRIM33NFKB1
SCHEMBL15272151 0.91 CDK4 (0.84) CDK4CCND1TRIM24TRIM33NFKB1
SCHEMBL28268121 0.85 CDK4 (0.74) CDK4CCND1TRIM24TRIM33NFKB1
SCHEMBL11070320 0.83 CDK4 (0.70) CDK4CCND1TRIM24TRIM33NFKB1
SCHEMBL16476616 0.83 CDK4 (0.70) CDK4CCND1TRIM24TRIM33NFKB1
SCHEMBL5820790 0.83 CDK4 (0.70) CDK4CCND1TRIM24TRIM33CA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 940 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119708403-A Resorcinol-cinnamaldehyde resin, its preparation method, modified vulcanized rubber composition and application 华奇(中国)化工有限公司 2025-03-28 CN claimed
CN-119506883-A Metal etching preparation process 科峻成精密科技(东莞)有限公司 2025-02-25 CN claimed
US-12234384-B2 Adhesion-improving composition for textile material and associated reinforcing textile material PORCHER INDUSTRIES (FR) 2025-02-25 US claimed
CN-119258081-A Composition for inhibiting methicillin-resistant staphylococcus epidermidis and application thereof 中山市尤利卡天然药物有限公司 2025-01-07 CN claimed
US-20240197755-A1 Pharmaceutical composition for use in the therapeutic treatment of cancer and complications of cancer MONKAM NITCHEU GUY FAUSTIN (FR) 2024-06-20 US claimed
WO-2024107938-A2 POLYPHENOL LIPID NANOPARTICLES AND METHODS OF USE THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) 2024-05-23 WO claimed
CN-115785383-B Preparation method of self-repairing polyurethane containing DA bond and acylhydrazone bond through double crosslinking 浙江工业大学 2023-09-05 CN claimed
CN-116589648-A Self-repairing polyurethane based on acylhydrazone bond, and preparation method and application thereof 陕西科技大学 2023-08-15 CN claimed
WO-2023128710-A1 TABLET CONTAINING MIXED EXTRACT OF CINNAMOMI RAMULUS AND MOUTAN RADICIS CORTEX AS ACTIVE INGREDIENT AND COMPOSITION DESIGNED TO ADMINISTER SPECIFIC DOSAGE THEREOF FOR TREATMENT 주식회사 큐라클 2023-07-06 WO claimed
CN-116356330-A Modified amino acid composite corrosion inhibitor and preparation method and application thereof 华南理工大学 2023-06-30 CN claimed
EP-1292269-B1 AGENT FOR DYEING KERATIN CONTAINING FIBERS HENKEL KGAA (DE) 2005-02-09 EP claimed
US-6790239-B1 COMBINATION OF AROMATIC ALDEHYDES OR KETONES AND CH-ACTIVE COMPOUNDS HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (DE) 2004-09-14 US claimed
CN-1095834-C Quinolinone derivatives and antiallergic agent containing said quinolinone derivatives as active ingredient DAINIPPON INK & CHEMICALS (JP) 2002-12-11 CN claimed
US-20020103134-A1 Modulators of beta-amyloid peptide aggregation comprising D-amino acids PRAECIS PHARMACEUTICALS INC. 2002-08-01 US claimed
EP-0785190-B1 Quinolinone derivative and antiallergic agent with said quinolinone derivative as the active ingredient DAINIPPON INK & CHEMICALS (JP) 2000-08-16 EP claimed
US-5985242-A PEPTIDE OF 3 TO 5 D-AMINO ACIDS; MAY BE MODIFIED AT AMINO-AND/OR CARBOXY TERMINUS; FOR TREATMENT OF AMYLOIDOSIS, ALZHEIMER'S DISEASE PRAECIS PHARMACEUTICALS, INC. (US) 1999-11-16 US claimed
EP-0929574-A1 MODULATORS OF beta-AMYLOID PEPTIDE AGGREGATION COMPRISING D-AMINO ACIDS Praecis Pharmaceuticals Incorporated (US) 1999-07-21 EP claimed
WO-1998008868-A9 MODULATORS OF β-AMYLOID PEPTIDE AGGREGATION COMPRISING D-AMINO ACIDS 1998-05-28 WO claimed
WO-1998008868-A1 MODULATORS OF β-AMYLOID PEPTIDE AGGREGATION COMPRISING D-AMINO ACIDS PRAECIS PHARMACEUTICALS INCORPORATED (US) 1998-03-05 WO claimed
EP-0593230-A1 Metal corrosion inhibiting compositions HALLIBURTON COMPANY (US) 1994-04-20 EP claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020103134-A1 Modulators of beta-amyloid peptide aggregation comprising D-amino acids IAPP, APP, VIP CDK4 1809/4885CCND1 1915/4885TRIM24 2936/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.