Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1L1 | Q9UHC9 | 10/20 | 0.54 |
| ▸ | USP2 | O75604 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | INPP5D | Q92835 | 1/20 | 0.48 |
| ▸ | CDC25A | P30304 | 3/20 | 0.44 |
| ▸ | POLA1 | P09884 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | SRD5A1 | P18405 | 3/20 | 0.42 |
| ▸ | SRD5A2 | P31213 | 3/20 | 0.42 |
| ▸ | CDC25B | P30305 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL131383 | 0.82 | NPC1L1 (0.70) | NPC1L1USP2LMNAMEN1TP53 | |
| SCHEMBL14007452 | 0.82 | NPC1L1 (0.70) | NPC1L1USP2LMNAMEN1TP53 | |
| SCHEMBL1937432 | 0.82 | CYP2D6 (0.60) | NPC1L1USP2LMNAMEN1TP53 | |
| SCHEMBL15107562 | 0.82 | NPC1L1 (0.70) | NPC1L1USP2LMNAMEN1TP53 | |
| SCHEMBL13988168 | 0.82 | NPC1L1 (0.70) | NPC1L1USP2LMNAMEN1TP53 | |
| SCHEMBL24632922 | 0.81 | NPC1L1 (0.57) | NPC1L1USP2LMNAMEN1TP53 | |
| SCHEMBL22872157 | 0.81 | NPC1L1 (0.57) | NPC1L1USP2LMNAMEN1TP53 | |
| SCHEMBL30088637 | 0.81 | NPC1L1 (0.57) | NPC1L1USP2LMNAMEN1TP53 | |
| SCHEMBL3466236 | 0.81 | NPC1L1 (0.57) | NPC1L1USP2LMNAMEN1TP53 | |
| SCHEMBL23628433 | 0.78 | NPC1L1 (0.59) | NPC1L1USP2LMNAMEN1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3474848-A1 | METHOD FOR PRODUCTION OF NOVEL GALETERONE ANALOGS AND USES THEREOF | University of Maryland, Baltimore (US) | 2019-05-01 | — | — | EP | disclosed |
| WO-2017223320-A1 | METHOD FOR PRODUCTION OF NOVEL GALETERONE ANALOGS AND USES THEREOF | UNIVERSITY OF MARYLAND, BALTIMORE (US) | 2017-12-28 | — | — | WO | disclosed |