Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGLL | Q99685 | 2/20 | 0.43 |
| ▸ | PTGS1 | P23219 | 4/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | CA12 | O43570 | 2/20 | 0.35 |
| ▸ | CA1 | P00915 | 2/20 | 0.35 |
| ▸ | CA2 | P00918 | 2/20 | 0.35 |
| ▸ | CA4 | P22748 | 2/20 | 0.35 |
| ▸ | CA9 | Q16790 | 2/20 | 0.35 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | FAAH | O00519 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19668514 | 0.95 | MGLL (0.45) | MGLLPTGS1PTGS2TSHRSMN1; SMN2 | |
| SCHEMBL28516664 | 0.92 | MGLL (0.46) | MGLLPTGS1PTGS2TSHRSMN1; SMN2 | |
| SCHEMBL26519953 | 0.88 | MGLL (0.49) | MGLLPTGS1PTGS2TSHRSMN1; SMN2 | |
| SCHEMBL29441383 | 0.88 | MGLL (0.55) | MGLLPTGS1PTGS2SMN1; SMN2HPGD | |
| SCHEMBL29869052 | 0.88 | MGLL (0.55) | MGLLPTGS1PTGS2SMN1; SMN2HPGD | |
| SCHEMBL24621693 | 0.88 | MGLL (0.55) | MGLLPTGS1PTGS2SMN1; SMN2HPGD | |
| SCHEMBL10018583 | 0.88 | MGLL (0.55) | MGLLPTGS1PTGS2SMN1; SMN2HPGD | |
| SCHEMBL29608026 | 0.88 | MGLL (0.55) | MGLLPTGS1PTGS2SMN1; SMN2HPGD | |
| SCHEMBL29869032 | 0.88 | MGLL (0.55) | MGLLPTGS1PTGS2SMN1; SMN2HPGD | |
| SCHEMBL30259429 | 0.88 | MGLL (0.55) | MGLLPTGS1PTGS2SMN1; SMN2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3475284-A1 | PYRROLOBENZODIAZEPINES AND CONJUGATES THEREOF | Mersana Therapeutics, Inc. (US) | 2019-05-01 | — | — | EP | disclosed |
| WO-2017223275-A1 | PYRROLOBENZODIAZEPINES AND CONJUGATES THEREOF | MERSANA THERAPEUTICS, INC. (US) | 2017-12-28 | — | — | WO | disclosed |