Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP30 | Q70CQ3 | 3/20 | 0.50 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.43 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | NAAA | Q02083 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | NAMPT | P43490 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17653036 | 0.97 | HDAC1 (0.50) | USP30HDAC3HDAC1ALDH1A1MEN1 | |
| SCHEMBL17661474 | 0.95 | HDAC3 (0.50) | USP30HDAC3HDAC1ALDH1A1MEN1 | |
| SCHEMBL17661480 | 0.94 | HDAC3 (0.49) | USP30HDAC3HDAC1ALDH1A1MEN1 | |
| SCHEMBL17653039 | 0.93 | USP30 (0.52) | USP30HDAC3HDAC1ALDH1A1MEN1 | |
| SCHEMBL17661475 | 0.91 | USP30 (0.52) | USP30HDAC3HDAC1ALDH1A1MEN1 | |
| SCHEMBL17661481 | 0.90 | USP30 (0.51) | USP30HDAC3HDAC1ALDH1A1MEN1 | |
| SCHEMBL17661233 | 0.88 | HDAC1 (0.52) | USP30HDAC3HDAC1ALDH1A1MEN1 | |
| SCHEMBL17652983 | 0.86 | RAB9A (0.54) | HDAC3HDAC1ALDH1A1MEN1KMT2A | |
| SCHEMBL17661479 | 0.84 | USP30 (0.49) | USP30HDAC3HDAC1ALDH1A1MEN1 | |
| SCHEMBL19747788 | 0.84 | MEN1 (0.53) | USP30HDAC3HDAC1ALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3472156-B1 | COMPOUNDS, COMPOSITIONS, AND METHODS FOR INCREASING CFTR ACTIVITY | PROTEOSTASIS THERAPEUTICS INC (US) | 2023-06-07 | — | — | EP | disclosed |
| EP-3472156-A1 | COMPOUNDS, COMPOSITIONS, AND METHODS FOR INCREASING CFTR ACTIVITY | Proteostasis Therapeutics, Inc. (US) | 2019-04-24 | — | — | EP | disclosed |
| WO-2017223188-A1 | COMPOUNDS, COMPOSITIONS, AND METHODS FOR INCREASING CFTR ACTIVITY | PROTEOSTASIS THERAPEUTICS, INC. (US) | 2017-12-28 | — | — | WO | disclosed |