Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR5 | P51681 | 10/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | CCR2 | P41597 | 2/20 | 0.43 |
| ▸ | CCR7 | P32248 | 1/20 | 0.43 |
| ▸ | RARB | P10826 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | CCR3 | P51677 | 1/20 | 0.41 |
| ▸ | CCR4 | P51679 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17870855 | 0.87 | CCR5 (0.58) | CCR5CCR2CCR7RARBCCR3 | |
| SCHEMBL17870854 | 0.87 | CCR5 (0.58) | CCR5CCR2CCR7RARBCCR3 | |
| SCHEMBL17870850 | 0.84 | CCR5 (0.52) | CCR5CCR2CCR7RARBCCR3 | |
| SCHEMBL17870851 | 0.84 | CCR5 (0.52) | CCR5CCR2CCR7RARBCCR3 | |
| SCHEMBL3458880 | 0.84 | CCR5 (0.61) | CCR5KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL3458877 | 0.84 | CCR5 (0.61) | CCR5KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL3458608 | 0.81 | CCR5 (0.61) | CCR5KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL3458607 | 0.81 | CCR5 (0.61) | CCR5KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL3458606 | 0.81 | CCR5 (0.61) | CCR5KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL3458969 | 0.79 | CCR5 (0.56) | CCR5KDM4EALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3471718-A1 | PURIFIED CENICRIVIROC AND PURIFIED INTERMEDIATES FOR MAKING CENICRIVIROC | Tobira Therapeutics, Inc. (US) | 2019-04-24 | — | — | EP | disclosed |
| WO-2017223155-A1 | PURIFIED CENICRIVIROC AND PURIFIED INTERMEDIATES FOR MAKING CENICRIVIROC | TOBIRA THERAPEUTICS, INC. (US) | 2017-12-28 | — | — | WO | disclosed |