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SCHEMBL1974908

SCHEMBL1974908

N#Cc1nc(C(=O)NCC(=O)O)c(O)c2scc(-c3ccc(F)cc3)c12.O=C(O)CNC(=O)c1ncc2cc(-c3ccc(F)cc3)sc2c1O

nearest known ligand 0.49

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
▸ EGLN1 Q9GZT9 18/20 0.49
▸ FLT1 P17948 1/20 0.40
▸ EGLN3 Q9H6Z9 1/20 0.40
▸ EGLN2 Q96KS0 4/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL966104 0.89 EGLN1 (0.56) EGLN1FLT1EGLN3EGLN2
SCHEMBL969590 0.84 EGLN1 (0.58) EGLN1FLT1EGLN3EGLN2
SCHEMBL4973349 0.84 EGLN1 (0.51) EGLN1EGLN2
SCHEMBL966893 0.75 EGLN1 (0.57) EGLN1
SCHEMBL965528 0.75 EGLN1 (0.52) EGLN1
SCHEMBL967008 0.75 EGLN1 (0.56) EGLN1FLT1EGLN3EGLN2
SCHEMBL966959 0.74 EGLN1 (0.53) EGLN1FLT1EGLN3
SCHEMBL967496 0.73 EGLN1 (0.56) EGLN1FLT1EGLN3EGLN2
SCHEMBL967699 0.73 EGLN1 (0.50) EGLN1FLT1EGLN3EGLN2
SCHEMBL1974053 0.72 PTGS1 (0.39) —

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1866318-B1 THIENOPYRIDINE COMPOUNDS, AND METHODS OF USE THEREOF FIBROGEN INC (US) 2011-06-22 — — EP disclosed
EP-1866318-A2 THIENOPYRIDINE COMPOUNDS, AND METHODS OF USE THEREOF FIBROGEN, INC. (US) 2007-12-19 — — EP disclosed
WO-2006094292-A2 THIENOPYRIDINE COMPOUNDS, AND METHODS OF USE THEREOF FIBROGEN, INC. (US) 2006-09-08 — — WO disclosed