Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 18/20 | 0.53 |
| ▸ | STK17B | O94768 | 1/20 | 0.46 |
| ▸ | EGLN3 | Q9H6Z9 | 3/20 | 0.43 |
| ▸ | FTO | Q9C0B1 | 2/20 | 0.43 |
| ▸ | VEGFA | P15692 | 1/20 | 0.43 |
| ▸ | FLT1 | P17948 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL968156 | 0.92 | EGLN1 (0.48) | EGLN1EGLN3FTOVEGFAFLT1 | |
| SCHEMBL969590 | 0.89 | EGLN1 (0.58) | EGLN1EGLN3FTOVEGFAFLT1 | |
| SCHEMBL967699 | 0.84 | EGLN1 (0.50) | EGLN1EGLN3FTOVEGFAFLT1 | |
| SCHEMBL967393 | 0.83 | EGLN1 (0.65) | EGLN1FTO | |
| SCHEMBL967011 | 0.82 | EGLN1 (0.51) | EGLN1EGLN3FTO | |
| SCHEMBL2881261 | 0.82 | EGLN1 (0.51) | EGLN1 | |
| SCHEMBL27723247 | 0.80 | EGLN1 (0.53) | EGLN1STK17BEGLN3FTO | |
| SCHEMBL5281870 | 0.80 | EGLN1 (0.48) | EGLN1 | |
| SCHEMBL1974111 | 0.78 | MAPT (0.52) | STK17B | |
| SCHEMBL966335 | 0.77 | EGLN1 (0.46) | EGLN1FTO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 37 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8703795-B2 | Thienopyridine compounds, and methods of use thereof | FIBROGEN, INC. (US) | 2014-04-22 | — | — | US | claimed |
| JP-4792048-B2 | — | — | 2011-10-12 | — | — | JP | claimed |
| EP-1866318-B1 | THIENOPYRIDINE COMPOUNDS, AND METHODS OF USE THEREOF | FIBROGEN INC (US) | 2011-06-22 | — | — | EP | claimed |
| JP-2008531736-A | — | — | 2008-08-14 | — | — | JP | claimed |
| CN-101166745-A | Thienopyridine compounds and methods of use thereof | FIBROGEN INC (US) | 2008-04-23 | — | — | CN | claimed |
| EP-1866318-A2 | THIENOPYRIDINE COMPOUNDS, AND METHODS OF USE THEREOF | FIBROGEN, INC. (US) | 2007-12-19 | — | — | EP | claimed |
| WO-2006094292-A2 | THIENOPYRIDINE COMPOUNDS, AND METHODS OF USE THEREOF | FIBROGEN, INC. (US) | 2006-09-08 | — | — | WO | claimed |
| US-20060199836-A1 | Novel thienopyridine compounds, and methods of use thereof | FIBROGEN, INC. | 2006-09-07 | — | — | US | claimed |
| US-9775902-B2 | Compounds and methods for treatment of stroke | FIBROGEN, INC (US) | 2017-10-03 | — | — | US | disclosed |
| US-9000006-B2 | Thienopyridine compounds, and methods of use thereof | FIBROGEN, INC. (US) | 2015-04-07 | — | — | US | disclosed |
| US-20140221422-A1 | NOVEL THIENOPYRIDINE COMPOUNDS, AND METHODS OF USE THEREOF | FIBROGEN, INC. (US) | 2014-08-07 | — | — | US | disclosed |
| US-8703795-B2 | Thienopyridine compounds, and methods of use thereof | FIBROGEN, INC. (US) | 2014-04-22 | — | — | US | disclosed |
| US-8530404-B2 | Compounds and methods for treatment of cancer | FIBROGEN, INC. (US) | 2013-09-10 | — | — | US | disclosed |
| US-8318703-B2 | Methods for improving kidney function | FIBROGEN, INC. (US) | 2012-11-27 | — | — | US | disclosed |
| US-20070259960-A1 | Compounds and methods for treatment of stroke | FIBROGEN, INC. (US) | 2007-11-08 | — | — | US | disclosed |
| US-20070004627-A1 | Compounds and methods for treatment of cancer | FIBROGEN, INC. (US) | 2007-01-04 | — | — | US | disclosed |
| WO-2006133391-A2 | IMPROVED TREATMENT FOR ANEMIA USING A HIF-ALPHA STABILISING AGENT | FIBROGEN, INC. (US) | 2006-12-14 | — | — | WO | disclosed |
| US-20060276477-A1 | Treatment method for anemia | FIBROGEN, INC. (US) | 2006-12-07 | — | — | US | disclosed |
| WO-2006094292-A2 | THIENOPYRIDINE COMPOUNDS, AND METHODS OF USE THEREOF | FIBROGEN, INC. (US) | 2006-09-08 | — | — | WO | disclosed |
| US-20060199836-A1 | Novel thienopyridine compounds, and methods of use thereof | FIBROGEN, INC. | 2006-09-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140221422-A1 | NOVEL THIENOPYRIDINE COMPOUNDS, AND METHODS OF USE THEREOF | HIF1AN, HIF1A, EGLN2 | EGLN1 7/4885STK17B 1047/4885EGLN3 4/4885 |
| US-20060199836-A1 | Novel thienopyridine compounds, and methods of use thereof | HIF1AN, HIF1A, EGLN2 | EGLN1 7/4885STK17B 1047/4885EGLN3 4/4885 |
| US-20060276477-A1 | Treatment method for anemia | THPO, EPOR, MPL | EGLN1 85/4885STK17B 2595/4885EGLN3 12/4885 |
| US-20070259960-A1 | Compounds and methods for treatment of stroke | PLAT, SERPINE1, PLG | EGLN1 740/4885STK17B 4077/4885EGLN3 494/4885 |
| US-20070004627-A1 | Compounds and methods for treatment of cancer | TP53, MKI67, HDGF | EGLN1 98/4885STK17B 2872/4885EGLN3 36/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.