Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | UHRF1 | Q96T88 | 1/20 | 0.35 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.35 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.35 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.32 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.32 |
| ▸ | HTR2A | P28223 | 1/20 | 0.32 |
| ▸ | HTR2C | P28335 | 1/20 | 0.32 |
| ▸ | HTR2B | P41595 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | CCR1 | P32246 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | CCR5 | P51681 | 1/20 | 0.30 |
| ▸ | DRD2 | P14416 | 1/20 | 0.30 |
| ▸ | DRD1 | P21728 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7923006 | 0.81 | HTR2C (0.33) | UHRF1PDK2PDK4HTR2AHTR2C | |
| SCHEMBL12733902 | 0.81 | UHRF1 (0.34) | UHRF1PDK2PDK4ALOX5SLC6A2 | |
| SCHEMBL4201428 | 0.75 | — | — | |
| SCHEMBL28293248 | 0.74 | — | — | |
| SCHEMBL17771334 | 0.73 | HTR2A (0.39) | PDK2SLC6A2SLC6A4SLC6A3HTR2A | |
| SCHEMBL7925225 | 0.68 | CCR1 (0.33) | PDK2PDK4CCR1RAB9ACCR5 | |
| SCHEMBL6845116 | 0.68 | DRD2 (0.38) | PDK2PDK4CCR1RAB9ACCR5 | |
| SCHEMBL10238794 | 0.68 | DRD2 (0.38) | PDK2PDK4CCR1RAB9ACCR5 | |
| SCHEMBL12654064 | 0.68 | KDM1A (0.52) | — | |
| SCHEMBL20153299 | 0.67 | UHRF1 (0.40) | UHRF1ALOX5CCR1RAB9ACCR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2488513-B1 | 2,6-Diaminopyridine compounds for treating diseases associated with amyloid proteins or for treating ocular diseases | AC IMMUNE SA (CH) | 2017-12-27 | — | — | EP | disclosed |