Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 4/20 | 0.54 |
| ▸ | DDB1 | Q16531 | 3/20 | 0.54 |
| ▸ | GSPT1 | P15170 | 2/20 | 0.54 |
| ▸ | IKZF3 | Q9UKT9 | 1/20 | 0.54 |
| ▸ | DRD4 | P21917 | 1/20 | 0.54 |
| ▸ | IKZF1 | Q13422 | 5/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.49 |
| ▸ | IKZF2 | Q9UKS7 | 8/20 | 0.47 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.47 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.44 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL61737 | 0.92 | CRBN (0.62) | CRBNDDB1GSPT1IKZF3DRD4 | |
| SCHEMBL25242491 | 0.81 | IKZF1 (0.63) | CRBNDDB1GSPT1IKZF3IKZF1 | |
| SCHEMBL13363701 | 0.79 | CRBN (0.59) | CRBNDDB1GSPT1IKZF3IKZF1 | |
| SCHEMBL4455248 | 0.78 | CRBN (0.64) | CRBNDDB1GSPT1IKZF3CYP2C19 | |
| SCHEMBL12965232 | 0.78 | CRBN (0.62) | CRBNDDB1GSPT1IKZF3IKZF1 | |
| SCHEMBL25280863 | 0.78 | IKZF1 (0.61) | CRBNDDB1GSPT1IKZF3IKZF1 | |
| SCHEMBL25280864 | 0.78 | IKZF1 (0.61) | CRBNDDB1GSPT1IKZF3IKZF1 | |
| SCHEMBL68717 | 0.78 | CRBN (0.63) | CRBNDDB1GSPT1IKZF3CYP2C19 | |
| SCHEMBL61287 | 0.77 | CRBN (0.65) | CRBNDDB1GSPT1IKZF3CYP2C19 | |
| Hydrochloric Acid SCHEMBL62814 | 0.77 | CRBN (0.62) | CRBNDDB1GSPT1IKZF3CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2985281-B1 | ISOINDOLINE COMPOUNDS FOR USE IN THE TREATMENT OF CANCER | CELGENE CORP (US) | 2017-12-27 | — | — | EP | disclosed |