Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSPT1 | P15170 | 3/20 | 0.42 |
| ▸ | CRBN | Q96SW2 | 3/20 | 0.42 |
| ▸ | DDB1 | Q16531 | 2/20 | 0.42 |
| ▸ | IKZF3 | Q9UKT9 | 1/20 | 0.42 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.39 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.39 |
| ▸ | KDM1A | O60341 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | SLC5A7 | Q9GZV3 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | FLT3 | P36888 | 1/20 | 0.38 |
| ▸ | TNF | P01375 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | HTR7 | P34969 | 1/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL70133 | 0.88 | CRBN (0.56) | GSPT1CRBNDDB1IKZF3CYP2C19 | |
| SCHEMBL68778 | 0.82 | CRBN (0.56) | GSPT1CRBNDDB1IKZF3UTS2R | |
| SCHEMBL18402521 | 0.81 | ROCK1 (0.44) | GSPT1CRBNDDB1IKZF3CYP2C19 | |
| SCHEMBL62041 | 0.80 | CRBN (0.58) | GSPT1CRBNDDB1IKZF3CYP2C19 | |
| SCHEMBL20470581 | 0.78 | DDB1 (0.50) | GSPT1CRBNDDB1IKZF3CYP2C19 | |
| SCHEMBL24113860 | 0.78 | UTS2R (0.42) | GSPT1CRBNDDB1IKZF3UTS2R | |
| SCHEMBL68285 | 0.78 | CRBN (0.56) | GSPT1CRBNDDB1IKZF3CYP2C19 | |
| SCHEMBL60346 | 0.78 | CRBN (0.56) | GSPT1CRBNDDB1IKZF3CYP2C19 | |
| SCHEMBL21863913 | 0.78 | ROCK2 (0.42) | GSPT1CRBNDDB1IKZF3UTS2R | |
| SCHEMBL69209 | 0.78 | TNF (0.58) | GSPT1CRBNDDB1IKZF3CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2985281-B1 | ISOINDOLINE COMPOUNDS FOR USE IN THE TREATMENT OF CANCER | CELGENE CORP (US) | 2017-12-27 | — | — | EP | disclosed |