Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 8/20 | 0.76 |
| ▸ | OPRM1 | P35372 | 10/20 | 0.48 |
| ▸ | OPRD1 | P41143 | 7/20 | 0.48 |
| ▸ | OPRK1 | P41145 | 5/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19764452 | 0.90 | KDM1A (0.76) | KDM1AOPRM1OPRD1OPRK1 | |
| SCHEMBL19764448 | 0.86 | KDM1A (0.73) | KDM1AOPRD1 | |
| SCHEMBL17987988 | 0.86 | KDM1A (1.00) | KDM1AOPRM1OPRD1 | |
| SCHEMBL17963551 | 0.79 | KDM1A (0.67) | KDM1AOPRM1OPRD1OPRK1 | |
| SCHEMBL17987996 | 0.76 | KDM1A (1.00) | KDM1A | |
| SCHEMBL30219292 | 0.76 | KDM1A (0.62) | KDM1AOPRM1OPRD1OPRK1 | |
| SCHEMBL13424483 | 0.76 | OPRM1 (0.47) | KDM1AOPRM1OPRD1OPRK1 | |
| SCHEMBL12442825 | 0.76 | OPRM1 (0.47) | KDM1AOPRM1OPRD1OPRK1 | |
| SCHEMBL17988049 | 0.75 | KDM1A (0.57) | KDM1AOPRM1OPRD1OPRK1 | |
| SCHEMBL1118855 | 0.75 | KDM1A (0.54) | KDM1AOPRM1OPRD1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180009735-A1 | THERAPEUTIC COMPOUNDS AND USES THEREOF | GENENTECH, INC. (US) | 2018-01-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180009735-A1 | THERAPEUTIC COMPOUNDS AND USES THEREOF | KDM1B, HDAC1, DOT1L | KDM1A 7/4885OPRM1 2284/4885OPRD1 3253/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.