Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 4/20 | 0.71 |
| ▸ | BRD4 | O60885 | 16/20 | 0.71 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.64 |
| ▸ | MEN1 | O00255 | 1/20 | 0.64 |
| ▸ | CASP1 | P29466 | 1/20 | 0.64 |
| ▸ | CASP7 | P55210 | 1/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.64 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.64 |
| ▸ | PKM | P14618 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28101549 | 0.90 | RORC (0.75) | RORCBRD4KDM4EALDH1A1MEN1 | |
| SCHEMBL28458568 | 0.86 | BRD4 (0.64) | RORCBRD4KDM4EALDH1A1MEN1 | |
| SCHEMBL28101538 | 0.86 | RORC (0.71) | RORCBRD4KDM4EALDH1A1MEN1 | |
| SCHEMBL17992508 | 0.86 | RORC (0.84) | RORCBRD4KDM4EALDH1A1MEN1 | |
| SCHEMBL29437248 | 0.86 | RORC (0.84) | RORCBRD4KDM4EALDH1A1MEN1 | |
| SCHEMBL19764639 | 0.85 | RORC (0.82) | RORCBRD4KDM4EALDH1A1MEN1 | |
| SCHEMBL29437245 | 0.85 | RORC (0.82) | RORCBRD4KDM4EALDH1A1MEN1 | |
| SCHEMBL16866199 | 0.83 | RORC (1.00) | RORCBRD4KDM4EALDH1A1MEN1 | |
| SCHEMBL16862775 | 0.83 | BRD4 (1.00) | RORCBRD4KDM4EALDH1A1PKM | |
| Tert-Butyl Formate SCHEMBL28101540 | 0.82 | RORC (0.69) | RORCBRD4KDM4EALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10183010-B2 | 2-oxo-1,2-dihydrobenzo[cd]indole compound and use thereof | GUANGZHOU INSTITUTES OF BIOMEDICINE AND HEALTH, CHINESE ACADEMY OF SCIENCES (CN) | 2019-01-22 | — | — | US | claimed |
| US-10183010-B2 | 2-oxo-1,2-dihydrobenzo[cd]indole compound and use thereof | GUANGZHOU INSTITUTES OF BIOMEDICINE AND HEALTH, CHINESE ACADEMY OF SCIENCES (CN) | 2019-01-22 | — | — | US | disclosed |
| US-10183010-B2 | 2-oxo-1,2-dihydrobenzo[cd]indole compound and use thereof | GUANGZHOU INSTITUTES OF BIOMEDICINE AND HEALTH, CHINESE ACADEMY OF SCIENCES (CN) | 2019-01-22 | — | — | US | disclosed |
| US-20180008574-A1 | 2-oxo-1,2-dihydrobenzo[cd]indole compound and use thereof | GUANGZHOU INSTITUTES OF BIOMEDICINE AND HEALTH, CHINESE ACADEMY OF SCIENCES (CN) | 2018-01-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180008574-A1 | 2-oxo-1,2-dihydrobenzo[cd]indole compound and use thereof | BRD4, BRD3, BRD1 | RORC 26/4885BRD4 1/4885KDM4E 796/4885 |
| US-10183010-B2 | 2-oxo-1,2-dihydrobenzo[cd]indole compound and use thereof | BRD4, BRD3, BRD1 | RORC 26/4885BRD4 1/4885KDM4E 796/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.