Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.39 |
| ▸ | CDK4 | P11802 | 1/20 | 0.38 |
| ▸ | CCND1 | P24385 | 1/20 | 0.38 |
| ▸ | YEATS4 | O95619 | 1/20 | 0.36 |
| ▸ | GFER | P55789 | 2/20 | 0.36 |
| ▸ | KDM1A | O60341 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | SPR | P35270 | 1/20 | 0.35 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3240757 | 0.94 | MEN1 (0.42) | MEN1KMT2AMAPK14CDK4CCND1 | |
| SCHEMBL3252673 | 0.94 | MEN1 (0.42) | MEN1KMT2AMAPK14CDK4CCND1 | |
| SCHEMBL4098014 | 0.94 | MEN1 (0.42) | MEN1KMT2AMAPK14CDK4CCND1 | |
| SCHEMBL11357600 | 0.88 | CDK4 (0.42) | MEN1KMT2AMAPK14CDK4CCND1 | |
| SCHEMBL21230205 | 0.88 | RECQL (0.42) | MEN1KMT2AMAPK14YEATS4LMNA | |
| SCHEMBL11357718 | 0.88 | CDK4 (0.42) | MEN1KMT2AMAPK14CDK4CCND1 | |
| SCHEMBL21230204 | 0.88 | CDK4 (0.42) | MEN1KMT2AMAPK14CDK4CCND1 | |
| SCHEMBL19775229 | 0.87 | ACKR3 (0.41) | MEN1KMT2AMAPK14YEATS4LMNA | |
| SCHEMBL16373443 | 0.86 | KMT2A (0.42) | MEN1KMT2AMAPK14YEATS4GFER | |
| SCHEMBL21230194 | 0.86 | RAB9A (0.42) | MEN1KMT2AMAPK14YEATS4LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2182809-B1 | THERAPEUTIC ISOXAZOLE COMPOUNDS | DART NEUROSCIENCE (CAYMAN) LTD (KY) | 2018-01-17 | — | — | EP | disclosed |