Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPRB | P23467 | 10/20 | 0.38 |
| ▸ | LTA4H | P09960 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.32 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.32 |
| ▸ | CPB1 | P15086 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | DHFR | P00374 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL500905 | 0.88 | PTPRB (0.52) | PTPRB | |
| SCHEMBL29794287 | 0.88 | PTPRB (0.52) | PTPRB | |
| SCHEMBL500904 | 0.88 | PTPRB (0.52) | PTPRB | |
| SCHEMBL21514666 | 0.80 | PTPRB (0.34) | PTPRBMTNR1AMTNR1B | |
| SCHEMBL19775498 | 0.80 | VCP (0.43) | PTPRBALDH1A1LMNA | |
| SCHEMBL468205 | 0.80 | PTPRB (0.42) | PTPRB | |
| SCHEMBL21699639 | 0.79 | VCP (0.43) | PTPRBPTK2 | |
| SCHEMBL20810397 | 0.78 | PTPRB (0.42) | PTPRB | |
| SCHEMBL20060097 | 0.77 | PTPRB (0.37) | PTPRBALDH1A1 | |
| SCHEMBL24767309 | 0.75 | PTPRB (0.41) | PTPRBRAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3607821-A1 | COMPOSITIONS, FORMULATIONS AND METHODS FOR TREATING OCULAR DISEASES | Aerpio Therapeutics, Inc. (US) | 2020-02-12 | — | — | EP | disclosed |
| EP-2451279-B1 | BENZOSULFONAMIDE DERIVATIVES, COMPOSITIONS THEREOF, AND THEIR USE IN PREVENTING METASTASIS OF CANCER CELLS | AERPIO THERAPEUTICS INC (US) | 2019-03-13 | — | — | EP | disclosed |
| EP-2385763-B1 | METHODS FOR TREATING VASCULAR LEAK SYNDROME | AERPIO THERAPEUTICS INC (US) | 2018-04-18 | — | — | EP | disclosed |
| EP-2624916-B1 | THIADIAZOLE DERIVATIVES FOR USE IN THE TREATMENT OF OCULAR EDEMA | AERPIO THERAPEUTICS INC (US) | 2018-01-17 | — | — | EP | disclosed |