Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 1/20 | 0.43 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | PKM | P14618 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | DRD4 | P21917 | 3/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.36 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.33 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.33 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.33 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21469022 | 1.00 | PRMT5 (0.43) | PRMT5WDR77ALDH1A1PKMLMNA | |
| SCHEMBL28723953 | 0.89 | DRD4 (0.39) | PRMT5WDR77DRD4TSHRSMN1; SMN2 | |
| SCHEMBL28723955 | 0.89 | DRD4 (0.39) | PRMT5WDR77DRD4TSHRSMN1; SMN2 | |
| SCHEMBL21468971 | 0.84 | PRMT5 (0.38) | PRMT5WDR77ALDH1A1PKMLMNA | |
| SCHEMBL5963778 | 0.83 | S1PR4 (0.52) | PRMT5WDR77ALDH1A1PKMLMNA | |
| SCHEMBL21459911 | 0.82 | S1PR4 (0.37) | PRMT5WDR77ALDH1A1PKMLMNA | |
| SCHEMBL21459912 | 0.82 | S1PR4 (0.37) | PRMT5WDR77ALDH1A1PKMLMNA | |
| SCHEMBL23552189 | 0.81 | PRMT5 (0.36) | PRMT5WDR77ALDH1A1PKMLMNA | |
| SCHEMBL19776487 | 0.81 | PRMT5 (0.36) | PRMT5WDR77ALDH1A1PKMLMNA | |
| SCHEMBL6211440 | 0.76 | ALDH1A1 (0.39) | PRMT5WDR77ALDH1A1PKMLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018013776-A1 | TRICYCLIC HETEROARYL-SUBSTITUTED QUINOLINE AND AZAQUINOLINE COMPOUNDS AS PAR4 INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2018-01-18 | — | — | WO | disclosed |