Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.60 |
| ▸ | LMNA | P02545 | 2/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.60 |
| ▸ | HTT | P42858 | 1/20 | 0.60 |
| ▸ | NPC1 | O15118 | 7/20 | 0.57 |
| ▸ | RAB9A | P51151 | 6/20 | 0.57 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | RAF1 | P04049 | 1/20 | 0.47 |
| ▸ | HPGDS | O60760 | 1/20 | 0.47 |
| ▸ | GRM5 | P41594 | 1/20 | 0.44 |
| ▸ | CTSK | P43235 | 1/20 | 0.43 |
| ▸ | JMJD6 | Q6NYC1 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.41 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13472630 | 0.84 | NPC1 (0.63) | SMN1; SMN2ALDH1A1LMNAKDM4EHTT | |
| SCHEMBL13472107 | 0.83 | SMN1; SMN2 (0.54) | SMN1; SMN2ALDH1A1LMNAKDM4EHTT | |
| SCHEMBL2629347 | 0.81 | SMN1; SMN2 (0.64) | SMN1; SMN2ALDH1A1LMNAKDM4EHTT | |
| SCHEMBL18421576 | 0.81 | NPC1 (0.65) | SMN1; SMN2ALDH1A1LMNAKDM4EHTT | |
| SCHEMBL20064373 | 0.80 | ALDH1A1 (0.51) | SMN1; SMN2ALDH1A1LMNAKDM4EHTT | |
| Hydrochloric Acid SCHEMBL18131819 | 0.79 | SMN1; SMN2 (0.62) | SMN1; SMN2ALDH1A1LMNAKDM4EHTT | |
| SCHEMBL12444121 | 0.79 | SMN1; SMN2 (0.62) | SMN1; SMN2ALDH1A1LMNAKDM4EHTT | |
| SCHEMBL5629836 | 0.79 | SMN1; SMN2 (0.62) | SMN1; SMN2ALDH1A1LMNAKDM4EHTT | |
| SCHEMBL20718369 | 0.79 | SMN1; SMN2 (0.54) | SMN1; SMN2ALDH1A1LMNAKDM4EHTT | |
| SCHEMBL10289302 | 0.78 | NPC1 (0.62) | SMN1; SMN2ALDH1A1LMNAKDM4EHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3747870-A1 | PYRIDAZINOL COMPOUND, DERIVATIVE THEREOF, PREPARATION METHOD THEREFOR, HERBICIDAL COMPOSITION AND USE THEREOF | Qingdao KingAgroot Chemical Compound Co., Ltd. (CN) | 2020-12-09 | — | — | EP | disclosed |
| WO-2018013676-A1 | SOMATOSTATIN MODULATORS AND USES THEREOF | Crinetics Pharmaceuticals, Inc. (US) | 2018-01-18 | — | — | WO | disclosed |