Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MARK3 | P27448 | 4/20 | 0.40 |
| ▸ | CDK2 | P24941 | 2/20 | 0.39 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.39 |
| ▸ | TTK | P33981 | 1/20 | 0.39 |
| ▸ | AXL | P30530 | 9/20 | 0.39 |
| ▸ | MERTK | Q12866 | 9/20 | 0.39 |
| ▸ | GSK3B | P49841 | 2/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.39 |
| ▸ | JAK2 | O60674 | 2/20 | 0.38 |
| ▸ | SGK1 | O00141 | 1/20 | 0.38 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.38 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.38 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.38 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.38 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.38 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.38 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.38 |
| ▸ | ABL1 | P00519 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12597221 | 0.99 | GSK3B (0.40) | MARK3CDK2CCNA2TTKAXL | |
| SCHEMBL12597806 | 0.93 | GSK3B (0.39) | MARK3CDK2AXLMERTKGSK3B | |
| SCHEMBL12597407 | 0.92 | GSK3B (0.39) | MARK3CDK2AXLMERTKGSK3B | |
| SCHEMBL11908405 | 0.91 | MARK3 (0.40) | MARK3CDK2CCNA2TTKAXL | |
| SCHEMBL11907769 | 0.86 | MERTK (0.39) | MARK3CDK2AXLMERTKGSK3B | |
| SCHEMBL12597423 | 0.84 | PIM1 (0.43) | MARK3CDK2AXLMERTKGSK3B | |
| SCHEMBL3723670 | 0.83 | CHRM1 (0.42) | MARK3CDK2AXLMERTKGSK3B | |
| SCHEMBL11929500 | 0.83 | CHRM1 (0.42) | MARK3CDK2AXLMERTKGSK3B | |
| SCHEMBL1982173 | 0.83 | CHEK1 (0.45) | CDK2CCNA2TTKCHEK1NTRK1 | |
| SCHEMBL11909077 | 0.83 | MARK3 (0.43) | MARK3CDK2AXLMERTKGSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011070299-A1 | TRI-SUBSTITUTED 9H-BETA-CARBOLINE (OR 9H-PYRIDO[3,4-B]INDOLE) DERIVATIVES, PREPARATION OF SAME AND THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2011-06-16 | — | — | WO | disclosed |