Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 2/20 | 0.45 |
| ▸ | MAP4K1 | Q92918 | 2/20 | 0.44 |
| ▸ | PLAU | P00749 | 1/20 | 0.43 |
| ▸ | PIM1 | P11309 | 6/20 | 0.42 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.42 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.41 |
| ▸ | CDK2 | P24941 | 1/20 | 0.41 |
| ▸ | TTK | P33981 | 1/20 | 0.41 |
| ▸ | FYN | P06241 | 2/20 | 0.39 |
| ▸ | IGF1R | P08069 | 1/20 | 0.39 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.39 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.37 |
| ▸ | KIT | P10721 | 1/20 | 0.37 |
| ▸ | FLT3 | P36888 | 1/20 | 0.37 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.36 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.36 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1978484 | 0.91 | CHEK1 (0.42) | CHEK1MAP4K1PLAUPIM1MAP4K4 | |
| SCHEMBL12597208 | 0.91 | CHEK1 (0.42) | CHEK1MAP4K1PIM1MAP4K4CCNA2 | |
| SCHEMBL1983422 | 0.89 | CHEK1 (0.42) | CHEK1PIM1MAP4K4CCNA2CDK2 | |
| SCHEMBL12597220 | 0.85 | TLR7 (0.41) | MAP4K1CCNA2CDK2TTKIGF1R | |
| SCHEMBL1980514 | 0.83 | PIM1 (0.44) | PIM1PIM3PIM2TLR8TLR7 | |
| SCHEMBL12597221 | 0.83 | GSK3B (0.40) | CHEK1MAP4K1PLAUPIM1CCNA2 | |
| SCHEMBL1978206 | 0.83 | MARK3 (0.40) | CHEK1PLAUPIM1CCNA2CDK2 | |
| SCHEMBL1979326 | 0.82 | SUV39H2 (0.45) | IGF1R | |
| SCHEMBL1979541 | 0.81 | MAP4K1 (0.49) | MAP4K1PIM1PIM3PIM2MAPT | |
| SCHEMBL1984109 | 0.81 | CHEK1 (0.48) | CHEK1PIM1MAP4K4PIM3PIM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011070299-A1 | TRI-SUBSTITUTED 9H-BETA-CARBOLINE (OR 9H-PYRIDO[3,4-B]INDOLE) DERIVATIVES, PREPARATION OF SAME AND THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2011-06-16 | — | — | WO | disclosed |
| WO-2011070299-A1 | TRI-SUBSTITUTED 9H-BETA-CARBOLINE (OR 9H-PYRIDO[3,4-B]INDOLE) DERIVATIVES, PREPARATION OF SAME AND THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2011-06-16 | — | — | WO | disclosed |