Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | ADORA3 | P0DMS8 | 4/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 4/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 4/20 | 0.36 |
| ▸ | ADORA2B | P29275 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | PDE2A | O00408 | 1/20 | 0.33 |
| ▸ | DHFR | P00374 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19783074 | 0.84 | RECQL (0.38) | RECQLPOLBMAPTTSHRPDE2A | |
| SCHEMBL30189475 | 0.84 | RECQL (0.38) | RECQLPOLBMAPTTSHRPDE2A | |
| SCHEMBL19783030 | 0.82 | HSD17B10 (0.46) | RECQLPOLBADORA3ADORA2AADORA1 | |
| SCHEMBL30189804 | 0.82 | HSD17B10 (0.46) | RECQLPOLBADORA3ADORA2AADORA1 | |
| SCHEMBL28383665 | 0.73 | GAA (0.35) | ADORA3ADORA2AADORA1ADORA2BMAPT | |
| SCHEMBL30187549 | 0.70 | F2RL3 (0.56) | — | |
| SCHEMBL19783230 | 0.70 | F2RL3 (0.56) | — | |
| SCHEMBL10049899 | 0.68 | PDE10A (0.44) | POLBMAPTGAAPDE2ASMN1; SMN2 | |
| SCHEMBL12109852 | 0.67 | MAPT (0.45) | MAPTTSHRGAASMN1; SMN2ALOX15 | |
| SCHEMBL16268335 | 0.67 | USP2 (0.33) | ADORA3ADORA2AADORA1ADORA2BALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018013774-A1 | BICYCLIC HETEROARYL SUBSTITUTED COMPOUNDS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2018-01-18 | — | — | WO | disclosed |