Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | GRM5 | P41594 | 2/20 | 0.34 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.34 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | MAOA | P21397 | 1/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.33 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.32 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.32 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.32 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30189775 | 0.83 | KDM4E (0.34) | LMNAGRM5CYP11B1CYP11B2KDM4E | |
| SCHEMBL30189706 | 0.83 | PDE10A (0.33) | LMNAGRM5CYP11B1CYP11B2KDM4E | |
| SCHEMBL19783559 | 0.83 | KDM4E (0.34) | LMNAGRM5CYP11B1CYP11B2KDM4E | |
| SCHEMBL19782543 | 0.83 | PDE10A (0.33) | LMNAGRM5CYP11B1CYP11B2KDM4E | |
| SCHEMBL19783328 | 0.76 | L3MBTL1 (0.44) | LMNAALDH1A1HPGDPOLB | |
| SCHEMBL30189767 | 0.76 | L3MBTL1 (0.44) | LMNAALDH1A1HPGDPOLB | |
| SCHEMBL19782862 | 0.76 | CCR1 (0.34) | LMNAGRM5CYP11B1CYP11B2ALDH1A1 | |
| SCHEMBL30189953 | 0.76 | CCR1 (0.34) | LMNAGRM5CYP11B1CYP11B2ALDH1A1 | |
| SCHEMBL19783287 | 0.73 | CCR1 (0.33) | LMNAGRM5CYP11B1CYP11B2KDM4E | |
| SCHEMBL30189704 | 0.73 | CCR1 (0.33) | LMNAGRM5CYP11B1CYP11B2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018013774-A1 | BICYCLIC HETEROARYL SUBSTITUTED COMPOUNDS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2018-01-18 | — | — | WO | disclosed |