Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19123966 | 0.91 | POLB (0.38) | ALDH1A1POLBL3MBTL1NPSR1MEN1 | |
| SCHEMBL14605293 | 0.83 | CA1 (0.37) | SMN1; SMN2USP2ALDH1A1POLBL3MBTL1 | |
| SCHEMBL30341350 | 0.81 | CA1 (0.41) | SMN1; SMN2USP2ALDH1A1POLBL3MBTL1 | |
| SCHEMBL12251504 | 0.78 | POLB (0.41) | SMN1; SMN2USP2ALDH1A1HSD17B10POLB | |
| SCHEMBL21795443 | 0.78 | CA12 (0.46) | SMN1; SMN2ALDH1A1POLBL3MBTL1KDM4E | |
| SCHEMBL2603254 | 0.76 | SMN1; SMN2 (0.33) | SMN1; SMN2ALDH1A1 | |
| SCHEMBL2606114 | 0.76 | KDM4E (0.42) | SMN1; SMN2ALDH1A1HSD17B10POLBL3MBTL1 | |
| SCHEMBL24767584 | 0.74 | MEN1 (0.40) | SMN1; SMN2USP2ALDH1A1HSD17B10POLB | |
| SCHEMBL19402777 | 0.74 | POLB (0.36) | SMN1; SMN2POLBL3MBTL1NPSR1KDM4E | |
| SCHEMBL799178 | 0.72 | L3MBTL1 (0.50) | SMN1; SMN2USP2ALDH1A1HSD17B10POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180015096-A1 | HIGHLY ACTIVE ANTI-NEOPLASTIC AND ANTI-PROLIFERATIVE AGENTS | G1 THERAPEUTICS, INC. (US) | 2018-01-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180015096-A1 | HIGHLY ACTIVE ANTI-NEOPLASTIC AND ANTI-PROLIFERATIVE AGENTS | MKI67, PCNA, HRAS | SMN1; SMN2 2179/4885USP2 2873/4885ALDH1A1 1438/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.