Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | ABL1 | P00519 | 11/20 | 0.35 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | XBP1 | P17861 | 1/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.33 |
| ▸ | RELA | Q04206 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22591000 | 0.94 | KMT2A (0.37) | KMT2AABL1MAPK8ALDH1A1TSHR | |
| SCHEMBL19784087 | 0.92 | ALDH1A1 (0.35) | KMT2AALDH1A1TSHRPOLBMEN1 | |
| SCHEMBL19784203 | 0.91 | KMT2A (0.37) | KMT2AABL1MAPK8ALDH1A1POLB | |
| SCHEMBL19783567 | 0.90 | IRAK4 (0.38) | KMT2AALDH1A1TSHRPOLBIRAK4 | |
| SCHEMBL21220086 | 0.90 | IRAK4 (0.38) | KMT2AALDH1A1TSHRPOLBIRAK4 | |
| SCHEMBL22591922 | 0.90 | ALDH1A1 (0.35) | KMT2AMAPK8ALDH1A1TSHRPOLB | |
| SCHEMBL22590974 | 0.90 | KMT2A (0.37) | KMT2AABL1MAPK8IRAK4 | |
| SCHEMBL19783947 | 0.89 | ALDH1A1 (0.35) | KMT2AALDH1A1TSHRPOLBMEN1 | |
| SCHEMBL21220044 | 0.89 | ALDH1A1 (0.35) | KMT2AALDH1A1TSHRPOLBMEN1 | |
| SCHEMBL21220038 | 0.88 | KMT2A (0.39) | KMT2AALDH1A1TSHRPOLBMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3481823-B1 | 7-SUBSTITUTED 1-PYRIDYL-NAPHTHYRIDINE-3-CARBOXYLIC ACID AMIDES AND USE THEREOF | Bayer Pharma AG (DE) | 2020-10-28 | — | — | EP | disclosed |
| WO-2018011017-A1 | 7-SUBSTITUTED 1-PYRIDYL-NAPHTHYRIDINE-3-CARBOXYLIC ACID AMIDES AND USE THEREOF | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2018-01-18 | — | — | WO | disclosed |