Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 11/20 | 0.37 |
| ▸ | PDE4A | P27815 | 9/20 | 0.37 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.33 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.33 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.31 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22331753 | 0.90 | P2RX7 (0.38) | P2RX7KCNH2PDE4AMALT1CNR2 | |
| SCHEMBL19784175 | 0.88 | P2RX7 (0.35) | P2RX7KCNH2PDE4ATRPV1 | |
| SCHEMBL21220083 | 0.88 | P2RX7 (0.35) | P2RX7KCNH2PDE4ATRPV1 | |
| SCHEMBL19784025 | 0.86 | KCNH2 (0.40) | P2RX7KCNH2PDE4ATRPV1 | |
| SCHEMBL19784026 | 0.86 | KCNH2 (0.40) | P2RX7KCNH2PDE4ATRPV1 | |
| SCHEMBL19784186 | 0.85 | TRPV1 (0.36) | P2RX7KCNH2PDE4ATRPV1 | |
| SCHEMBL21220052 | 0.82 | TRPV1 (0.34) | P2RX7KCNH2PDE4ATRPV1 | |
| SCHEMBL19784185 | 0.82 | TRPV1 (0.34) | P2RX7KCNH2PDE4ATRPV1 | |
| SCHEMBL21220040 | 0.80 | PDE4A (0.35) | KCNH2PDE4A | |
| SCHEMBL19784110 | 0.80 | PDE4A (0.35) | KCNH2PDE4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3481823-B1 | 7-SUBSTITUTED 1-PYRIDYL-NAPHTHYRIDINE-3-CARBOXYLIC ACID AMIDES AND USE THEREOF | Bayer Pharma AG (DE) | 2020-10-28 | — | — | EP | disclosed |
| WO-2018011017-A1 | 7-SUBSTITUTED 1-PYRIDYL-NAPHTHYRIDINE-3-CARBOXYLIC ACID AMIDES AND USE THEREOF | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2018-01-18 | — | — | WO | disclosed |