Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM3 | P20309 | 2/20 | 0.68 |
| ▸ | ACHE | P22303 | 6/20 | 0.44 |
| ▸ | BCHE | P06276 | 3/20 | 0.44 |
| ▸ | MAOB | P27338 | 1/20 | 0.44 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | DRD4 | P21917 | 1/20 | 0.43 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.41 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19770223 | 1.00 | CHRM3 (0.68) | CHRM3ACHEBCHEMAOBDRD2 | |
| SCHEMBL19770158 | 0.86 | CHRM3 (0.70) | CHRM3ACHEBCHEMAOBDRD2 | |
| SCHEMBL19782287 | 0.86 | CHRM3 (0.70) | CHRM3ACHEBCHEMAOBDRD2 | |
| SCHEMBL19770163 | 0.86 | CHRM3 (0.70) | CHRM3ACHEBCHEMAOBDRD2 | |
| SCHEMBL19782239 | 0.84 | CHRM3 (0.70) | CHRM3ACHEBCHEMAOBDRD2 | |
| SCHEMBL19770166 | 0.84 | CHRM3 (0.70) | CHRM3ACHEBCHEMAOBDRD2 | |
| SCHEMBL19784564 | 0.84 | CHRM3 (0.69) | CHRM3ACHEBCHEMAOBDRD2 | |
| SCHEMBL19770164 | 0.84 | CHRM3 (0.69) | CHRM3ACHEBCHEMAOBDRD2 | |
| SCHEMBL19782505 | 0.83 | ACHE (0.47) | CHRM3ACHEBCHEMAOBDRD2 | |
| SCHEMBL19770172 | 0.81 | CHRM3 (0.68) | CHRM3ACHEBCHEMAOBDRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3484879-B1 | HYDROXYQUINOLINONE COMPOUNDS HAVING MUSCARINIC RECEPTOR ANTAGONIST AND BETA2 ADRENERGIC RECEPTOR AGONIST ACTIVITY | CHIESI FARM SPA (IT) | 2020-12-30 | — | — | EP | disclosed |
| WO-2018011090-A1 | HYDROXYQUINOLINONE COMPOUNDS HAVING MUSCARINIC RECEPTOR ANTAGONIST AND BETA2 ADRENERGIC RECEPTOR AGONIST ACTIVITY | CHIESI FARMACEUTICI S.P.A. (IT) | 2018-01-18 | — | — | WO | disclosed |