Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | CXCR2 | P25025 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KLK7 | P49862 | 3/20 | 0.39 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.39 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.39 |
| ▸ | CXCR1 | P25024 | 1/20 | 0.39 |
| ▸ | TACR1 | P25103 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30905353 | 0.87 | LMNA (0.42) | CXCR2TDP1L3MBTL1PTGS1ALDH1A1 | |
| SCHEMBL1820336 | 0.85 | PTGS1 (0.53) | KMT2ACXCR2PTGS1PTGS2MEN1 | |
| SCHEMBL28094253 | 0.82 | TDP1 (0.56) | KMT2ATDP1L3MBTL1KLK7MTNR1A | |
| SCHEMBL11373799 | 0.80 | PTGS1 (0.60) | KMT2ATDP1L3MBTL1PTGS1PTGS2 | |
| Hydrogen Peroxide SCHEMBL11143418 | 0.79 | CXCR2 (0.46) | KMT2ACXCR2TDP1PTGS1MEN1 | |
| SCHEMBL1821733 | 0.78 | PTGS1 (0.61) | KMT2ACXCR2PTGS1PTGS2MEN1 | |
| SCHEMBL8007159 | 0.77 | CXCR2 (0.43) | CXCR2TDP1PTGS1CXCR1ALDH1A1 | |
| SCHEMBL1578804 | 0.76 | KMT2A (0.69) | KMT2ATDP1L3MBTL1PTGS1PTGS2 | |
| SCHEMBL2494755 | 0.75 | FFAR1 (0.40) | CXCR2L3MBTL1MTNR1AMTNR1BALDH1A1 | |
| SCHEMBL2501280 | 0.75 | FFAR1 (0.40) | CXCR2L3MBTL1MTNR1AMTNR1BALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3484879-B1 | HYDROXYQUINOLINONE COMPOUNDS HAVING MUSCARINIC RECEPTOR ANTAGONIST AND BETA2 ADRENERGIC RECEPTOR AGONIST ACTIVITY | CHIESI FARM SPA (IT) | 2020-12-30 | — | — | EP | disclosed |
| WO-2018011090-A1 | HYDROXYQUINOLINONE COMPOUNDS HAVING MUSCARINIC RECEPTOR ANTAGONIST AND BETA2 ADRENERGIC RECEPTOR AGONIST ACTIVITY | CHIESI FARMACEUTICI S.P.A. (IT) | 2018-01-18 | — | — | WO | disclosed |