⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1337861 | 0.79 | — | — | |
| SCHEMBL25405042 | 0.79 | — | — | |
| SCHEMBL29984126 | 0.77 | HSD11B1 (0.31) | — | |
| SCHEMBL27080101 | 0.77 | HSD11B1 (0.31) | — | |
| SCHEMBL18338657 | 0.75 | — | — | |
| SCHEMBL21569208 | 0.75 | — | — | |
| SCHEMBL22980311 | 0.75 | — | — | |
| SCHEMBL22465644 | 0.75 | — | — | |
| SCHEMBL4554109 | 0.75 | — | — | |
| SCHEMBL1542908 | 0.75 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119731185-A | Synthesis of substituted 1-aryl-1 '-heteroaryl compounds and substituted 1,1' -bisheteroaryl compounds and analogs thereof | 爱彼特生物制药公司 | 2025-03-28 | — | — | CN | disclosed |
| CN-115461334-B | Benzimidazole derivative, and preparation method and medical application thereof | 深圳信立泰药业股份有限公司 | 2024-06-21 | — | — | CN | disclosed |
| EP-3484856-B1 | 2,5-DISUBSTITUTED 3-METHYL PYRAZINES AND 2,5,6-TRISUBSTITUTED 3-METHYL PYRAZINES AS ALLOSTERIC SHP2 INHIBITORS | REVOLUTION MEDICINES INC (US) | 2023-11-15 | — | — | EP | disclosed |
| US-11661401-B2 | 2,5-disubstituted 3-methyl pyrazines and 2,5,6-trisubstituted 3-methyl pyrazines as allosteric SHP2 inhibitors | Revolution Medicines, Inc. (US) | 2023-05-30 | — | — | US | disclosed |
| US-11661401-B2 | 2,5-disubstituted 3-methyl pyrazines and 2,5,6-trisubstituted 3-methyl pyrazines as allosteric SHP2 inhibitors | Revolution Medicines, Inc. (US) | 2023-05-30 | — | — | US | disclosed |
| CN-109689640-B | Compounds useful as immunomodulators | 百时美施贵宝公司 | 2022-01-04 | — | — | CN | disclosed |
| EP-3481815-B1 | 1,3-DIHYDROXY-PHENYL DERIVATIVES USEFUL AS IMMUNOMODULATORS | BRISTOL MYERS SQUIBB CO (US) | 2021-09-29 | — | — | EP | disclosed |
| WO-2021151062-A1 | HETEROCYCLIC COMPOUNDS AND USES THEREOF | THE TRUSTEES OF PRINCETON UNIVERISTY (US) | 2021-07-29 | — | — | WO | disclosed |
| US-10590105-B2 | 1,3-dihydroxy-phenyl derivatives useful as immunomodulators | BRISTOL-MEYERS SQUIBB COMPANY (US) | 2020-03-17 | — | — | US | disclosed |
| US-20190185450-A1 | 1,3-DIHYDROXY-PHENYL DERIVATIVES USEFUL AS IMMUNOMODULATORS | BRISTOL MYERS SQUIBB CO (US) | 2019-06-20 | — | — | US | disclosed |
| CN-109689640-A | It can be used as the compound of immunomodulator | 百时美施贵宝公司 | 2019-04-26 | — | — | CN | disclosed |
| CN-105658638-B | compounds with insecticidal activity | 拜耳作物科学股份公司 | 2018-07-06 | — | — | CN | disclosed |
| WO-2018013597-A1 | 2,5-DISUBSTITUTED 3-METHYL PYRAZINES AND 2,5,6-TRISUBSTITUTED 3-METHYL PYRAZINES AS ALLOSTERIC SHP2 INHIBITORS | Revolution Medicines, Inc. (US) | 2018-01-18 | — | — | WO | disclosed |
| WO-2018009505-A1 | 1,3-DIHYDROXY-PHENYL DERIVATIVES USEFUL AS IMMUNOMODULATORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2018-01-11 | — | — | WO | disclosed |
| CN-104797555-B | N-substituted benzamides and methods of use thereof | 基因泰克公司 | 2017-12-22 | — | — | CN | disclosed |
| CN-104854090-B | Heteroaryl derivative and its purposes | 雅各布斯制药公司 | 2017-12-15 | — | — | CN | disclosed |
| CN-103889986-B | Novel heterocyclic derivatives and their use | C&C新药研究所 | 2017-07-21 | — | — | CN | disclosed |
| CN-102574845-B | 1H-imidazo [4,5-c] qualone derivative | NOVARTIS AG (CH) | 2015-09-02 | — | — | CN | disclosed |
| CN-103889986-A | Novel heterocyclic derivatives and their use | C & C RES LAB | 2014-06-25 | — | — | CN | disclosed |
| CN-102574845-A | 1h-imidazo[4,5-c]quinolinone derivatives | NOVARTIS AG | 2012-07-11 | — | — | CN | disclosed |