Sugi Predict

Sugi Predict / Compounds / SCHEMBL19785422

SCHEMBL19785422

SCHEMBL19785422

CCOC(=O)c1ncc(C)nc1Cl

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ALDH1A1 P00352 3/20 0.51
▸ NPC1 O15118 2/20 0.51
▸ TP53 P04637 1/20 0.51
▸ MAPT P10636 1/20 0.51
▸ XBP1 P17861 1/20 0.51
▸ MAPK1 P28482 1/20 0.51
▸ HTT P42858 1/20 0.51
▸ NPSR1 Q6W5P4 1/20 0.51
▸ HSD17B10 Q99714 1/20 0.51
▸ TLR9 Q9NR96 1/20 0.51
▸ KDM5B Q9UGL1 2/20 0.50
▸ TARBP2 Q15633 2/20 0.43
▸ GLP1R P43220 1/20 0.43
▸ KDM4E B2RXH2 3/20 0.43
▸ CYP1A2 P05177 2/20 0.42
▸ MEN1 O00255 1/20 0.40
▸ KMT2A Q03164 1/20 0.40
▸ L3MBTL1 Q9Y468 2/20 0.40
▸ RAB9A P51151 1/20 0.40
▸ UBE2N P61088 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL26281338 0.87 ALDH1A1 (0.51) ALDH1A1NPC1TP53MAPTXBP1
SCHEMBL18779093 0.83 NPSR1 (0.47) ALDH1A1NPC1MAPTMAPK1NPSR1
SCHEMBL31279531 0.83 NPSR1 (0.47) ALDH1A1NPC1MAPTMAPK1NPSR1
SCHEMBL17648186 0.81 ALDH1A1 (0.47) ALDH1A1NPC1TP53MAPTXBP1
SCHEMBL29679865 0.81 ALDH1A1 (0.46) ALDH1A1NPC1TP53MAPTXBP1
SCHEMBL9592517 0.81 ALDH1A1 (0.46) ALDH1A1NPC1TP53MAPTXBP1
SCHEMBL18404967 0.80 ALDH1A1 (0.47) ALDH1A1NPC1TP53MAPTXBP1
SCHEMBL7541370 0.80 ALDH1A1 (0.44) ALDH1A1NPC1TP53MAPTXBP1
SCHEMBL7543209 0.79 ALDH1A1 (0.43) ALDH1A1NPC1TP53MAPTXBP1
SCHEMBL13205356 0.78 ALDH1A1 (0.46) ALDH1A1NPC1TP53MAPTXBP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 40 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4724070-A2 WRN INHIBITORS Nimbus Wadjet, Inc. (US) 2026-04-15 — — EP disclosed
US-12565476-B2 2,5-disubstituted 3-methyl pyrazines and 2,5,6-trisubstituted 3-methyl pyrazines as allosteric SHP2 inhibitors Revolution Medicines, Inc. (US) 2026-03-03 — — US disclosed
US-12528806-B2 WRN inhibitors NIMBUS WADJET, INC. (US) 2026-01-20 — — US disclosed
US-12421233-B2 WRN inhibitors NIMBUS WADJET, INC. (US) 2025-09-23 — — US disclosed
US-12344609-B2 WRN inhibitors NIMBUS WADJET, INC. (US) 2025-07-01 — — US disclosed
US-20250206738-A1 WRN INHIBITORS NIMBUS DISCOVERY, INC. 2025-06-26 — — US disclosed
WO-2025137599-A1 WRN INHIBITORS NIMBUS WADJET, INC. (US) 2025-06-26 — — WO disclosed
US-20250171442-A1 WRN INHIBITORS NIMBUS WADJET, INC. 2025-05-29 — — US disclosed
US-20250171441-A1 WRN INHIBITORS NIMBUS WADJET, INC. 2025-05-29 — — US disclosed
US-20250171440-A1 WRN INHIBITORS NIMBUS WADJET, INC. 2025-05-29 — — US disclosed
US-20210101870-A1 2,5-DISUBSTITUTED 3-METHYL PYRAZINES AND 2,5,6-TRISUBSTITUTED 3-METHYL PYRAZINES AS ALLOSTERIC SHP2 INHIBITORS WILMINGTON TRUST, NATIONAL ASSOCIATION, AS AGENT 2021-04-08 — — US disclosed
WO-2021018869-A1 1,2,4-OXADIAZOL-5-ONE DERIVATIVES FOR THE TREATMENT OF CANCER Basilea Pharmaceutica International AG (CH) 2021-02-04 — — WO disclosed
CN-111138412-A Spiro aromatic ring compound and application thereof 上海奕拓医药科技有限责任公司 2020-05-12 — — CN disclosed
US-10590090-B2 2,5-disubstituted 3-methyl pyrazines and 2,5,6-trisubstituted 3-methyl pyrazines as allosteric SHP2 inhibitors Revolution Medicines, Inc. (US) 2020-03-17 — — US disclosed
US-20190210977-A1 2,5-DISUBSTITUTED 3-METHYL PYRAZINES AND 2,5,6-TRISUBSTITUTED 3-METHYL PYRAZINES AS ALLOSTERIC SHP2 INHIBITORS WILMINGTON TRUST, NATIONAL ASSOCIATION, AS AGENT 2019-07-11 — — US disclosed
US-20190210977-A1 2,5-DISUBSTITUTED 3-METHYL PYRAZINES AND 2,5,6-TRISUBSTITUTED 3-METHYL PYRAZINES AS ALLOSTERIC SHP2 INHIBITORS WILMINGTON TRUST, NATIONAL ASSOCIATION, AS AGENT 2019-07-11 — — US disclosed
CN-109983001-A 2, 5-disubstituted 3-methylpyrazine and 2,5, 6-trisubstituted 3-methylpyrazine as allosteric SHP2 inhibitors 锐新医药公司 2019-07-05 — — CN disclosed
EP-3484856-A1 2,5-DISUBSTITUTED 3-METHYL PYRAZINES AND 2,5,6-TRISUBSTITUTED 3-METHYL PYRAZINES AS ALLOSTERIC SHP2 INHIBITORS Revolution Medicines, Inc. (US) 2019-05-22 — — EP disclosed
WO-2018013597-A1 2,5-DISUBSTITUTED 3-METHYL PYRAZINES AND 2,5,6-TRISUBSTITUTED 3-METHYL PYRAZINES AS ALLOSTERIC SHP2 INHIBITORS Revolution Medicines, Inc. (US) 2018-01-18 — — WO disclosed
WO-2018013597-A1 2,5-DISUBSTITUTED 3-METHYL PYRAZINES AND 2,5,6-TRISUBSTITUTED 3-METHYL PYRAZINES AS ALLOSTERIC SHP2 INHIBITORS Revolution Medicines, Inc. (US) 2018-01-18 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (11 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10590090-B2 2,5-disubstituted 3-methyl pyrazines and 2,5,6-trisubstituted 3-methyl pyrazines as allosteric SHP2 inhibitors PTPN5, PTPN22, PTPN2 ALDH1A1 4455/4885NPC1 4557/4885TP53 123/4885
US-20250206738-A1 WRN INHIBITORS WRN, BLM, RECQL ALDH1A1 3002/4885NPC1 2354/4885TP53 5/4885
US-20250171440-A1 WRN INHIBITORS WRN, BLM, RECQL ALDH1A1 3196/4885NPC1 2296/4885TP53 5/4885
US-20190210977-A1 2,5-DISUBSTITUTED 3-METHYL PYRAZINES AND 2,5,6-TRISUBSTITUTED 3-METHYL PYRAZINES AS ALLOSTERIC SHP2 INHIBITORS PTPN5, PTPN2, PTPN22 ALDH1A1 4411/4885NPC1 4242/4885TP53 241/4885
US-20250171441-A1 WRN INHIBITORS WRN, BLM, RECQL ALDH1A1 3002/4885NPC1 2354/4885TP53 5/4885
US-12421233-B2 WRN inhibitors WRN, BLM, RECQL ALDH1A1 3002/4885NPC1 2354/4885TP53 5/4885
US-12344609-B2 WRN inhibitors WRN, BLM, RECQL ALDH1A1 3196/4885NPC1 2296/4885TP53 5/4885
US-20210101870-A1 2,5-DISUBSTITUTED 3-METHYL PYRAZINES AND 2,5,6-TRISUBSTITUTED 3-METHYL PYRAZINES AS ALLOSTERIC SHP2 INHIBITORS PTPN5, PTPN22, PTPN2 ALDH1A1 4455/4885NPC1 4557/4885TP53 123/4885
US-20250171442-A1 WRN INHIBITORS WRN, BLM, RECQL ALDH1A1 2905/4885NPC1 2258/4885TP53 5/4885
US-12528806-B2 WRN inhibitors WRN, RECQL, BLM ALDH1A1 1817/4885NPC1 2533/4885TP53 53/4885
US-12565476-B2 2,5-disubstituted 3-methyl pyrazines and 2,5,6-trisubstituted 3-methyl pyrazines as allosteric SHP2 inhibitors PTPN5, PTPN6, PTPN2 ALDH1A1 4358/4885NPC1 1971/4885TP53 1111/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.