Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN11 | Q06124 | 20/20 | 0.77 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21927047 | 0.89 | PTPN11 (0.60) | PTPN11KCNH2 | |
| SCHEMBL21926668 | 0.89 | PTPN11 (0.59) | PTPN11KCNH2 | |
| SCHEMBL30141213 | 0.88 | PTPN11 (0.75) | PTPN11KCNH2 | |
| SCHEMBL31657083 | 0.88 | PTPN11 (0.72) | PTPN11KCNH2 | |
| SCHEMBL20347136 | 0.88 | PTPN11 (0.85) | PTPN11KCNH2 | |
| SCHEMBL24878923 | 0.87 | PTPN11 (0.58) | PTPN11KCNH2 | |
| SCHEMBL18328265 | 0.87 | PTPN11 (1.00) | PTPN11 | |
| SCHEMBL21926687 | 0.87 | PTPN11 (0.58) | PTPN11KCNH2 | |
| SCHEMBL28648881 | 0.86 | PTPN11 (0.82) | PTPN11 | |
| SCHEMBL24181700 | 0.86 | PTPN11 (0.57) | PTPN11KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018013597-A1 | 2,5-DISUBSTITUTED 3-METHYL PYRAZINES AND 2,5,6-TRISUBSTITUTED 3-METHYL PYRAZINES AS ALLOSTERIC SHP2 INHIBITORS | Revolution Medicines, Inc. (US) | 2018-01-18 | — | — | WO | disclosed |