Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN11 | Q06124 | 20/20 | 0.60 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24878923 | 0.91 | PTPN11 (0.58) | PTPN11KCNH2 | |
| SCHEMBL21927086 | 0.91 | PTPN11 (0.54) | PTPN11KCNH2 | |
| SCHEMBL19785449 | 0.89 | PTPN11 (0.77) | PTPN11KCNH2 | |
| SCHEMBL21926687 | 0.89 | PTPN11 (0.58) | PTPN11KCNH2 | |
| SCHEMBL21926707 | 0.89 | PTPN11 (0.53) | PTPN11KCNH2 | |
| SCHEMBL24181700 | 0.88 | PTPN11 (0.57) | PTPN11KCNH2 | |
| SCHEMBL24181556 | 0.86 | PTPN11 (0.55) | PTPN11KCNH2 | |
| SCHEMBL24879328 | 0.84 | PTPN11 (0.58) | PTPN11KCNH2 | |
| SCHEMBL24181585 | 0.84 | PTPN11 (0.51) | PTPN11KCNH2 | |
| SCHEMBL24181858 | 0.83 | PTPN11 (0.56) | PTPN11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3310774-B1 | COMPOUNDS AND COMPOSITIONS FOR INHIBITING THE ACTIVITY OF SHP2 | NOVARTIS AG (CH) | 2020-04-29 | — | — | EP | disclosed |