Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHB3 | P54753 | 4/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | CASP1 | P29466 | 1/20 | 0.44 |
| ▸ | CASP7 | P55210 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | STING1 | Q86WV6 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.42 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2176212 | 0.91 | NPC1 (0.49) | EPHB3KDM4EMAPTGAAALDH1A1 | |
| SCHEMBL3643070 | 0.89 | SMN1; SMN2 (0.44) | KDM4EHSD17B10MAPTALDH1A1HPGD | |
| SCHEMBL17320982 | 0.85 | EPHB3 (0.56) | EPHB3KDM4EHSD17B10MAPTALDH1A1 | |
| SCHEMBL15739719 | 0.85 | PIK3CD (0.46) | KDM4EHSD17B10MAPTALDH1A1ATM | |
| SCHEMBL3612196 | 0.85 | CA12 (0.46) | EPHB3KDM4EMAPTSTING1TSHR | |
| SCHEMBL25336177 | 0.84 | EPHB3 (0.44) | EPHB3KDM4EHSD17B10MAPTGAA | |
| SCHEMBL3612887 | 0.84 | EPHB3 (0.61) | EPHB3KDM4EMAPTALDH1A1TSHR | |
| SCHEMBL15717897 | 0.84 | KDM4E (0.43) | KDM4EHSD17B10GAAALDH1A1HPGD | |
| SCHEMBL21818039 | 0.84 | CYP1A2 (0.45) | KDM4EGAAATMSTING1ALOX15 | |
| SCHEMBL30204308 | 0.84 | PIK3CD (0.41) | EPHB3KDM4EHSD17B10MAPTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10781206-B2 | Tetrahydropyrazolopyridine compounds for the treatment of infectious diseases | HOFFMANN LA-ROCHE INC. (US) | 2020-09-22 | — | — | US | disclosed |
| US-10781206-B2 | Tetrahydropyrazolopyridine compounds for the treatment of infectious diseases | HOFFMANN LA-ROCHE INC. (US) | 2020-09-22 | — | — | US | disclosed |
| EP-3484883-B1 | NOVEL TETRAHYDROPYRAZOLOPYRIDINE COMPOUNDS FOR THE TREATMENT OF INFECTIOUS DISEASES | HOFFMANN LA ROCHE (CH) | 2020-04-15 | — | — | EP | disclosed |
| EP-3484883-B1 | NOVEL TETRAHYDROPYRAZOLOPYRIDINE COMPOUNDS FOR THE TREATMENT OF INFECTIOUS DISEASES | HOFFMANN LA ROCHE (CH) | 2020-04-15 | — | — | EP | disclosed |
| US-20190248786-A1 | NOVEL TETRAHYDROPYRAZOLOPYRIDINE COMPOUNDS FOR THE TREATMENT OF INFECTIOUS DISEASES | HOFFMANN-LA ROCHE INC. (US) | 2019-08-15 | — | — | US | disclosed |
| WO-2018011100-A1 | NOVEL TETRAHYDROPYRAZOLOPYRIDINE COMPOUNDS FOR THE TREATMENT OF INFECTIOUS DISEASES | F. HOFFMANN-LA ROCHE AG (CH) | 2018-01-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10781206-B2 | Tetrahydropyrazolopyridine compounds for the treatment of infectious diseases | QDPR, TPMT, CYP3A5 | EPHB3 2911/4885KDM4E 4441/4885HSD17B10 1851/4885 |
| US-20190248786-A1 | NOVEL TETRAHYDROPYRAZOLOPYRIDINE COMPOUNDS FOR THE TREATMENT OF INFECTIOUS DISEASES | QDPR, HAVCR2, TPMT | EPHB3 3119/4885KDM4E 4257/4885HSD17B10 2251/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.