Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 3/20 | 0.54 |
| ▸ | CTSL | P07711 | 2/20 | 0.49 |
| ▸ | CTSB | P07858 | 2/20 | 0.49 |
| ▸ | CTSS | P25774 | 2/20 | 0.49 |
| ▸ | CTSK | P43235 | 2/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.46 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26000432 | 0.86 | AKT1 (0.53) | AKT1CTSLCTSBCTSSCTSK | |
| SCHEMBL25278637 | 0.83 | CA12 (0.46) | CTSSCTSK | |
| SCHEMBL17108644 | 0.82 | AKT1 (0.49) | AKT1CTSKHDAC3HDAC1HDAC2 | |
| SCHEMBL29283681 | 0.81 | AKT1 (0.54) | AKT1CTSLCTSBCTSSCTSK | |
| SCHEMBL14861836 | 0.81 | AKT1 (0.53) | AKT1CTSLCTSBCTSSCTSK | |
| SCHEMBL18748472 | 0.78 | BCHE (0.47) | AKT1HDAC3HDAC1HDAC2NCOR2 | |
| SCHEMBL22771148 | 0.77 | APP (0.52) | AKT1CTSLCTSBCTSSHDAC3 | |
| SCHEMBL5024428 | 0.76 | AKT1 (0.51) | AKT1CTSLCTSBCTSSCTSK | |
| SCHEMBL31687528 | 0.76 | ACKR3 (0.55) | AKT1CTSK | |
| SCHEMBL7797088 | 0.76 | AKT1 (0.63) | AKT1CTSLCTSBCTSSCTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9873678-B2 | Chemical compounds | ASTRAZENECA AB (SE) | 2018-01-23 | — | — | US | disclosed |
| US-9873678-B2 | Chemical compounds | ASTRAZENECA AB (SE) | 2018-01-23 | — | — | US | disclosed |