Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 3/20 | 0.63 |
| ▸ | CTSS | P25774 | 4/20 | 0.59 |
| ▸ | CTSL | P07711 | 3/20 | 0.59 |
| ▸ | CTSB | P07858 | 3/20 | 0.59 |
| ▸ | CA12 | O43570 | 2/20 | 0.51 |
| ▸ | CA1 | P00915 | 1/20 | 0.51 |
| ▸ | CA7 | P43166 | 1/20 | 0.51 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.46 |
| ▸ | IDO1 | P14902 | 1/20 | 0.46 |
| ▸ | CTSK | P43235 | 1/20 | 0.45 |
| ▸ | CA9 | Q16790 | 1/20 | 0.45 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.44 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.44 |
| ▸ | PPARG | P37231 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL506498 | 0.89 | AKT1 (0.52) | AKT1CTSSCTSLCTSBPPARG | |
| SCHEMBL4748453 | 0.83 | AKT1 (0.62) | AKT1CTSSCTSLCTSBCA12 | |
| SCHEMBL8532390 | 0.81 | SMN1; SMN2 (0.56) | CTSSCTSLCTSBCA12CA1 | |
| SCHEMBL9098649 | 0.80 | AKT1 (0.71) | AKT1CTSSCTSLCTSBCA12 | |
| SCHEMBL7472970 | 0.79 | CTSS (0.62) | AKT1CTSSCTSLCTSBCA12 | |
| SCHEMBL19742566 | 0.79 | CTSL (0.57) | AKT1CTSSCTSLCTSBCA12 | |
| SCHEMBL19742676 | 0.79 | AKT1 (0.54) | AKT1CTSSCTSLCTSBCA12 | |
| SCHEMBL4254558 | 0.79 | CTSL (0.57) | AKT1CTSSCTSLCTSBCA12 | |
| SCHEMBL9756736 | 0.78 | AKT1 (0.53) | AKT1CTSSCTSLCTSBCA12 | |
| SCHEMBL4246507 | 0.78 | AKT1 (0.53) | AKT1CTSSCTSLCTSBCA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110105389-A1 | Macrocyclic Ghrelin Receptor Antagonists and Inverse Agonists and Methods of Using the Same | OCERA THERAPEUTICS, INC. | 2011-05-05 | — | — | US | disclosed |
| WO-2011053821-A1 | MACROCYCLIC GHRELIN RECEPTOR ANTAGONISTS AND INVERSE AGONISTS AND METHODS OF USING THE SAME | TRANZYME PHARMA, INC. (US) | 2011-05-05 | — | — | WO | disclosed |
| US-20010007869-A1 | ALPHA-SUBSTITTUTED PYRIDAZINO QUINOLINE COMPOUNDS | SYNGENTA LIMITED (GB) | 2001-07-12 | — | — | US | disclosed |
| EP-0736531-A1 | Alpha-substituted pyridazino quinoline compounds | ZENECA LIMITED (GB) | 1996-10-09 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110105389-A1 | Macrocyclic Ghrelin Receptor Antagonists and Inverse Agonists and Methods of Using the Same | GHSR, GHRHR, GIPR | AKT1 3790/4885CTSS 2800/4885CTSL 2458/4885 |
| US-20010007869-A1 | ALPHA-SUBSTITTUTED PYRIDAZINO QUINOLINE COMPOUNDS | CBR3, CHRNA1, CBR1 | AKT1 3803/4885CTSS 3891/4885CTSL 4283/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.