Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 5/20 | 0.50 |
| ▸ | PIK3CA | P42336 | 5/20 | 0.50 |
| ▸ | PIK3CB | P42338 | 5/20 | 0.50 |
| ▸ | PIK3CG | P48736 | 5/20 | 0.50 |
| ▸ | PDE10A | Q9Y233 | 8/20 | 0.36 |
| ▸ | CASP3 | P42574 | 2/20 | 0.36 |
| ▸ | NPR1 | P16066 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2729394 | 0.85 | PIK3CD (0.55) | PIK3CDPIK3CAPIK3CBPIK3CGPDE10A | |
| SCHEMBL19787854 | 0.80 | DHODH (0.41) | PIK3CDPIK3CAPIK3CBPIK3CGCASP3 | |
| SCHEMBL19787858 | 0.80 | PIK3CD (0.49) | PIK3CDPIK3CAPIK3CBPIK3CGPDE10A | |
| SCHEMBL19787857 | 0.78 | PIK3CD (0.48) | PIK3CDPIK3CAPIK3CBPIK3CGPDE10A | |
| SCHEMBL2720356 | 0.78 | PIK3CD (0.64) | PIK3CDPIK3CAPIK3CBPIK3CGNPR1 | |
| SCHEMBL13063161 | 0.77 | DHODH (0.33) | PIK3CDPIK3CAPIK3CBPIK3CGPDE10A | |
| SCHEMBL2720359 | 0.69 | PIK3CD (0.53) | PIK3CDPIK3CAPIK3CBPIK3CGKDM4E | |
| SCHEMBL2721579 | 0.68 | PIK3CD (0.63) | PIK3CDPIK3CAPIK3CBPIK3CGKDM4E | |
| SCHEMBL2720444 | 0.67 | PIK3CD (0.66) | PIK3CDPIK3CAPIK3CBPIK3CGCYP3A4 | |
| SCHEMBL2718662 | 0.67 | PIK3CD (0.49) | PIK3CDPIK3CAPIK3CBPIK3CGCASP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9873704-B2 | Heterocyclic compounds and their uses | AMGEN INC. (US) | 2018-01-23 | — | — | US | disclosed |