Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 16/20 | 0.49 |
| ▸ | PIK3CB | P42338 | 16/20 | 0.49 |
| ▸ | PIK3CG | P48736 | 16/20 | 0.49 |
| ▸ | PIK3CA | P42336 | 14/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.43 |
| ▸ | PDE10A | Q9Y233 | 4/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19787854 | 0.85 | DHODH (0.41) | PIK3CDPIK3CBPIK3CGPIK3CACYP3A4 | |
| SCHEMBL2729395 | 0.83 | PIK3CD (0.55) | PIK3CDPIK3CBPIK3CGPIK3CACYP3A4 | |
| SCHEMBL13063161 | 0.80 | DHODH (0.33) | PIK3CDPIK3CBPIK3CGPIK3CACYP3A4 | |
| SCHEMBL19787862 | 0.80 | PIK3CD (0.50) | PIK3CDPIK3CBPIK3CGPIK3CACYP3A4 | |
| SCHEMBL2717325 | 0.74 | PIK3CD (0.65) | PIK3CDPIK3CBPIK3CGPIK3CACYP3A4 | |
| SCHEMBL2729852 | 0.70 | DHODH (0.41) | PIK3CDPIK3CBPIK3CGPIK3CACYP3A4 | |
| SCHEMBL10120334 | 0.70 | PIK3CD (0.47) | PIK3CDCYP3A4CYP2C9 | |
| SCHEMBL13063145 | 0.69 | DHODH (0.43) | — | |
| SCHEMBL20072599 | 0.68 | CYP3A4 (0.39) | CYP3A4CYP2C9 | |
| SCHEMBL13062908 | 0.68 | TDO2 (0.38) | PIK3CDPIK3CBPIK3CGPIK3CACYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9873704-B2 | Heterocyclic compounds and their uses | AMGEN INC. (US) | 2018-01-23 | — | — | US | disclosed |