Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
| ▸ | MAOB | P27338 | 9/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4737237 | 0.84 | TP53 (0.45) | TP53CYP3A4TSHRALDH1A1SMN1; SMN2 | |
| SCHEMBL3241338 | 0.83 | KCNH2 (0.44) | ALDH1A1PRSS1 | |
| SCHEMBL1387264 | 0.78 | TP53 (0.35) | TP53CYP3A4TSHRALDH1A1SMN1; SMN2 | |
| SCHEMBL129082 | 0.78 | TP53 (0.59) | TP53CYP3A4TSHRALDH1A1SMN1; SMN2 | |
| SCHEMBL7527524 | 0.78 | TP53 (0.38) | TP53CYP3A4TSHRALDH1A1SMN1; SMN2 | |
| SCHEMBL23523394 | 0.78 | TSHR (0.41) | TSHRSMN1; SMN2HIF1AMAPK1LMNA | |
| SCHEMBL10573493 | 0.78 | MAPT (0.46) | ALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL5314704 | 0.77 | ALDH1A1 (0.32) | ALDH1A1 | |
| SCHEMBL19220421 | 0.76 | TP53 (0.39) | TP53CYP3A4TSHRALDH1A1SMN1; SMN2 | |
| SCHEMBL910975 | 0.75 | KMT2A (0.54) | TP53CYP3A4TSHRLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007069986-A1 | NEW OXABISPIDINE COMPOUNDS FOR THE TREATMENT OF CARDIAC ARRHYTHMIAS | ASTRAZENECA AB (SE) | 2007-06-21 | — | — | WO | claimed |
| WO-2011072064-A1 | S PIRO [CHROMAN - 4, 4 ' - IMIDAZOL] ONES AS BETA - SECRETASE INHIBITORS | ARRAY BIOPHARMA INC. (US) | 2011-06-16 | — | — | WO | disclosed |
| WO-2007069986-A1 | NEW OXABISPIDINE COMPOUNDS FOR THE TREATMENT OF CARDIAC ARRHYTHMIAS | ASTRAZENECA AB (SE) | 2007-06-21 | — | — | WO | disclosed |